Saraf A, Virshup DM, Strack S (2007) Differential expression of the B'beta regulatory subunit of protein phosphatase 2A modulates tyrosine hydroxylase phosphorylation and catecholamine synthesis. J Biol Chem 282, 573-80 17085438

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

Download

T203-p - ERK1 (rat) ▲

Modsite: HDHTGFLtEYVATRW SwissProt Entrez-Gene Orthologous residues ERK1 (human): T202‑p, ERK1 iso2 (human): T202‑p, ERK1 iso3 (human): T202‑p, ERK1 (mouse): T203‑p, ERK1 (rat): T203‑p, ERK1 (hamster): T192‑p Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes PHOSPHATASE PPP2CB (rat) transfection of wild-type enzyme Comments:  TH phosphorylation was decreased while ERK 1/2 was not.

Y205-p - ERK1 (rat) ▲

Modsite: HTGFLTEyVATRWYR SwissProt Entrez-Gene Orthologous residues ERK1 (human): Y204‑p, ERK1 iso2 (human): Y204‑p, ERK1 iso3 (human): Y204‑p, ERK1 (mouse): Y205‑p, ERK1 (rat): Y205‑p, ERK1 (hamster): Y194‑p Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes PHOSPHATASE PPP2CB (rat) transfection of wild-type enzyme Comments:  TH phosphorylation was decreased while ERK 1/2 was not.

T183-p - ERK2 (rat) ▲
Modsite: HDHTGFLtEYVATRW SwissProt Entrez-Gene Orthologous residues ERK2 (human): T185‑p, ERK2 (mouse): T183‑p, ERK2 (rat): T183‑p, ERK2 (chicken): T193‑p, ERK2 (cow): T185‑p Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes PHOSPHATASE PPP2CB (rat) transfection of wild-type enzyme Comments:  TH phosphorylation was decreased while ERK 1/2 was not.

Y185-p - ERK2 (rat) ▲
Modsite: HTGFLTEyVATRWYR SwissProt Entrez-Gene Orthologous residues ERK2 (human): Y187‑p, ERK2 (mouse): Y185‑p, ERK2 (rat): Y185‑p, ERK2 (chicken): Y195‑p, ERK2 (cow): Y187‑p Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes PHOSPHATASE PPP2CB (rat) transfection of wild-type enzyme Comments:  TH phosphorylation was decreased while ERK 1/2 was not.

S19-p - TH (rat) ▲

Modsite: KGFRRAVsEQDAKQA SwissProt Entrez-Gene Orthologous residues TH (human): S19‑p, TH iso2 (human): S19‑p, TH iso3 (human): S19‑p, TH iso4 (human): S19‑p, TH (mouse): S19‑p, TH (rat): S19‑p, TH (cow): S19‑p Characterization Methods used to characterize site in vivo:  microscopy-colocalization with upstream kinase, phospho-antibody, western blotting Disease tissue studied:  prostate cancer Relevant cell lines - cell types - tissues:  adrenal gland, neuron-brain, PC3 (prostate cell) Cellular systems studied:  cell lines, primary cultured cells, tissue Species studied:  human, rat Enzymes shown to modify site in vitro:  Type Enzyme PHOSPHATASE PPP2CB (rat) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes PHOSPHATASE PPP2CB (rat) transfection of wild-type enzyme Comments:  TH phosphorylation was decreased while ERK 1/2 was not. Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes okadaic_acid increase

S31-p - TH (rat) ▲

Modsite: KQAEAVTsPRFIGRR SwissProt Entrez-Gene Orthologous residues TH (human): S62‑p, TH iso2 (human): S58‑p, TH iso3 (human): S31‑p, TH iso4 (human): S35‑p, TH (mouse): S31‑p, TH (rat): S31‑p, TH (cow): S31‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Disease tissue studied:  prostate cancer Relevant cell lines - cell types - tissues:  adrenal gland, PC3 (prostate cell) Cellular systems studied:  cell lines, tissue Species studied:  human, rat Enzymes shown to modify site in vitro:  Type Enzyme PHOSPHATASE PPP2CB (rat) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes PHOSPHATASE PPP2CB (rat) transfection of wild-type enzyme Comments:  TH phosphorylation was decreased while ERK 1/2 was not. Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes okadaic_acid increase

S40-p - TH (rat) ▲

Modsite: RFIGRRQsLIEDARK SwissProt Entrez-Gene Orthologous residues TH (human): S71‑p, TH iso2 (human): S67‑p, TH iso3 (human): S40‑p, TH iso4 (human): S44‑p, TH (mouse): S40‑p, TH (rat): S40‑p, TH (cow): S40‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Disease tissue studied:  prostate cancer Relevant cell lines - cell types - tissues:  adrenal gland, PC3 (prostate cell) Cellular systems studied:  cell lines, tissue Species studied:  human, rat Enzymes shown to modify site in vitro:  Type Enzyme PHOSPHATASE PPP2CB (rat) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes PHOSPHATASE PPP2CB (rat) transfection of wild-type enzyme Comments:  TH phosphorylation was decreased while ERK 1/2 was not. Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes okadaic_acid increase