Leung KW, Pon YL, Wong RN, Wong AS (2006) Ginsenoside-Rg1 induces vascular endothelial growth factor expression through the glucocorticoid receptor-related phosphatidylinositol 3-kinase/Akt and beta-catenin/T-cell factor-dependent pathway in human endothelial cells. J Biol Chem 281, 36280-8 17008323

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S473-p - Akt1 (human) ▲

Modsite: RPHFPQFsysAsGtA SwissProt Entrez-Gene Orthologous residues Akt1 (human): S473‑p, Akt1 iso2 (human): S411‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  HUVEC (endothelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes ginsenoside-Rg1 increase mifepristone ginsenoside-Rg1 inhibit treatment-induced increase mifepristone no change compared to control

S37-p - CTNNB1 (human) ▲

Modsite: yLDsGIHsGATtTAP SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): S37‑p, CTNNB1 (mouse): S37‑p, CTNNB1 (rat): S37‑p, CTNNB1 (rabbit): S37‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HUVEC (endothelial) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (function):  protein degradation Effect of modification (process):  transcription, altered Comments:  regulates transcription of VEGF through altering of protein levels

S9-p - GSK3B (human) ▲

Modsite: SGRPRttsFAEsCkP SwissProt Entrez-Gene Orthologous residues GSK3B (human): S9‑p, GSK3B iso2 (human): S9‑p, GSK3B (mouse): S9‑p, GSK3B (rat): S9‑p, GSK3B (rabbit): S9‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  HUVEC (endothelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes ginsenoside-Rg1 increase LY294002 ginsenoside-Rg1 inhibit treatment-induced increase SH-6 ginsenoside-Rg1 inhibit treatment-induced increase PD98059 ginsenoside-Rg1 no effect upon treatment-induced increase mifepristone ginsenoside-Rg1 inhibit treatment-induced increase ginsenoside-Rg1 Akt1 (human) increase lithium increase