Koch T, et al. (1997) Site mutation in the rat mu-opioid receptor demonstrates the involvement of calcium/calmodulin-dependent protein kinase II in agonist-mediated desensitization. J Neurochem 69, 1767-70 9326307

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S261-p - MOR-1 (rat) ▲

Modsite: LMILRLKsVRMLsGS SwissProt Entrez-Gene Orthologous residues MOR‑1 (human): S263‑p, MOR‑1 iso5 (human): S263‑p, MOR‑1 (mouse): S261‑p, MOR‑1 (rat): S261‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial), oocyte [CPEB (mouse)] Cellular systems studied:  cell lines Species studied:  frog, human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE CAMK2A (human) mutation in upstream enzyme recognition motif Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes DAMGO increase Downstream Regulation Effect of modification (function):  receptor desensitization, altered Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays MOR-1 (rat) Not reported

S266-p - MOR-1 (rat) ▲

Modsite: LKsVRMLsGSKEKDR SwissProt Entrez-Gene Orthologous residues MOR‑1 (human): S268‑p, MOR‑1 iso5 (human): S268‑p, MOR‑1 (mouse): S266‑p, MOR‑1 (rat): S266‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial), oocyte [CPEB (mouse)] Cellular systems studied:  cell lines Species studied:  frog, human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE CAMK2A (human) mutation in upstream enzyme recognition motif Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes DAMGO increase Downstream Regulation Effect of modification (function):  receptor desensitization, altered