Curated Information
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Home > Curated Information Page > PubMed Id: 18457658
Jadhav T, Geetha T, Jiang J, Wooten MW (2008) Identification of a consensus site for TRAF6/p62 polyubiquitination. Biochem Biophys Res Commun 371, 521-4 18457658
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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K811-ub - TrkB (rat)
Modsite: TLLQNLAkAsPVyLD SwissProt Entrez-Gene
Orthologous residues
TrkB (human): K812‑ub, TrkB iso4 (human): K828‑ub, TrkB (mouse): K811‑ub, TrkB iso2 (mouse): , TrkB (rat): K811‑ub
Methods used to characterize site in vivo immunoprecipitation, modification-specific antibody, mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
UBIQUITIN LIGASE TRAF6 (human) co-immunoprecipitation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
BDNF increase
NGF increase
Downstream Regulation
Effect of modification (function):  phosphorylation
Effect of modification (process):  signaling pathway regulation
Comments:  NGF induced MAPK and Akt activation