Curated Information
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Home > Curated Information Page > PubMed Id: 17018529
Wu JH, et al. (2006) Regulation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-5 in vascular smooth muscle cells involves the phosphatase Shp2. J Biol Chem 281, 37758-72 17018529
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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Y578-p - PDGFRB (mouse)
Modsite: VssDGHEyIyVDPVQ SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y579‑p, PDGFRB (mouse): Y578‑p, PDGFRB (rat): Y578‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF increase
PDGF GRK5 (mouse) no effect upon treatment-induced increase homozygous null

Y739-p - PDGFRB (mouse)
Modsite: TGESDGGyMDMSKDE SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y740‑p, PDGFRB (mouse): Y739‑p, PDGFRB (rat): Y739‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF increase
PDGF GRK5 (mouse) inhibit treatment-induced increase

Y1008-p - PDGFRB (mouse)
Modsite: LDTSSVLyTAVQPNE SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y1009‑p, PDGFRB (mouse): Y1008‑p, PDGFRB (rat): Y1008‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF increase
PDGF GRK5 (mouse) inhibit treatment-induced increase homozygous null
Downstream Regulation
Effect of modification (function):  molecular association, regulation, phosphorylation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SHP-2 (human) Induces co-immunoprecipitation

Y1020-p - PDGFRB (mouse)
Modsite: PNESDNDyIIPLPDP SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y1021‑p, PDGFRB (mouse): Y1020‑p, PDGFRB (rat): Y1020‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF increase
PDGF GRK5 (mouse) augment treatment-induced increase homozygous null
PDGF GRK5 (mouse) inhibit treatment-induced increase

Y424-p - Src iso1 (mouse)
Modsite: RLIEDNEytARQGAK SwissProt Entrez-Gene
Orthologous residues
Src (human): Y419‑p, Src iso2 (human): Y425‑p, Src (mouse): Y418‑p, Src iso1 (mouse): Y424‑p, Src (rat): Y419‑p, Src (chicken): Y416‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF increase
PDGF GRK5 (mouse) inhibit treatment-induced increase homozygous null