Curated Information
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Home > Curated Information Page > PubMed Id: 17965020
Buxadé M, Morrice N, Krebs DL, Proud CG (2008) The PSF.p54nrb complex is a novel Mnk substrate that binds the mRNA for tumor necrosis factor alpha. J Biol Chem 283, 57-65 17965020
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S8-p - PSF (human)
Modsite: MSRDRFrsrGGGGGG SwissProt Entrez-Gene
Orthologous residues
PSF (human): S8‑p, PSF iso2 (human): S8‑p, PSF (mouse): S8‑p, PSF (rat): S8‑p
Characterization
Methods used to characterize site in vivo mass spectrometry (in vitro), phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE Mnk1 (human)
KINASE Mnk2 (human)
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol_ester increase
CGP57380 phorbol_ester inhibit treatment-induced increase

S283-p - PSF (human)
Modsite: EGFkANLsLLRRPGE SwissProt Entrez-Gene
Orthologous residues
PSF (human): S283‑p, PSF iso2 (human): S283‑p, PSF (mouse): S275‑p, PSF (rat): S275‑p
Characterization
Methods used to characterize site in vivo mass spectrometry (in vitro), phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE Mnk2 (human)
KINASE Mnk1 (human)