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Home > Curated Information Page > PubMed Id: 15473865
Swiercz R, Person MD, Bedford MT (2005) Ribosomal protein S2 is a substrate for mammalian PRMT3 (protein arginine methyltransferase 3). Biochem J 386, 85-91 15473865
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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R34-me - RPS2 (mouse)
Modsite: GGFGSGLrGrGrGrG SwissProt Entrez-Gene
Orthologous residues
RPS2 (human): R34‑me, RPS2 (mouse): R34‑me, RPS2 (rat): R34‑me
Characterization
Methods used to characterize site in vivo mutation of modification site, peptide sequencing, western blotting
Relevant cell lines - cell types - tissues:  3T3 (fibroblast), HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human, mouse
Enzymes shown to modify site in vitro
Type Enzyme
METHYLTRANSFERASE PRMT3 (mouse)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
METHYLTRANSFERASE PRMT3 (mouse) co-immunoprecipitation
Downstream Regulation
Effect of modification (function):  protein processing
Comments:  involved in ribosomal function and in the regulation of protein synthesis

R36-me - RPS2 (mouse)
Modsite: FGSGLrGrGrGrGrG SwissProt Entrez-Gene
Orthologous residues
RPS2 (human): R36‑me, RPS2 (mouse): R36‑me, RPS2 (rat): R36‑me
Characterization
Methods used to characterize site in vivo mutation of modification site, peptide sequencing, western blotting
Relevant cell lines - cell types - tissues:  3T3 (fibroblast), HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human, mouse
Enzymes shown to modify site in vitro
Type Enzyme
METHYLTRANSFERASE PRMT3 (mouse)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
METHYLTRANSFERASE PRMT3 (mouse) co-immunoprecipitation
Downstream Regulation
Effect of modification (function):  protein processing
Comments:  involved in ribosomal function and in the regulation of protein synthesis

R38-me - RPS2 (mouse)
Modsite: SGLrGrGrGrGrGrG SwissProt Entrez-Gene
Orthologous residues
RPS2 (human): R38‑me, RPS2 (mouse): R38‑me, RPS2 (rat): R38‑me
Characterization
Methods used to characterize site in vivo mutation of modification site, peptide sequencing, western blotting
Relevant cell lines - cell types - tissues:  3T3 (fibroblast), HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human, mouse
Enzymes shown to modify site in vitro
Type Enzyme
METHYLTRANSFERASE PRMT3 (mouse)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
METHYLTRANSFERASE PRMT3 (mouse) co-immunoprecipitation
Downstream Regulation
Effect of modification (function):  protein processing
Comments:  involved in ribosomal function and in the regulation of protein synthesis

R40-me - RPS2 (mouse)
Modsite: LrGrGrGrGrGrGrG SwissProt Entrez-Gene
Orthologous residues
RPS2 (human): R40‑me, RPS2 (mouse): R40‑me, RPS2 (rat): R40‑me
Characterization
Methods used to characterize site in vivo mutation of modification site, peptide sequencing, western blotting
Relevant cell lines - cell types - tissues:  3T3 (fibroblast), HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human, mouse
Enzymes shown to modify site in vitro
Type Enzyme
METHYLTRANSFERASE PRMT3 (mouse)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
METHYLTRANSFERASE PRMT3 (mouse) co-immunoprecipitation
Downstream Regulation
Effect of modification (function):  protein processing
Comments:  involved in ribosomal function and in the regulation of protein synthesis

R42-me - RPS2 (mouse)
Modsite: GrGrGrGrGrGrGrG SwissProt Entrez-Gene
Orthologous residues
RPS2 (human): R42‑me, RPS2 (mouse): R42‑me, RPS2 (rat): R42‑me
Characterization
Methods used to characterize site in vivo mutation of modification site, peptide sequencing, western blotting
Relevant cell lines - cell types - tissues:  3T3 (fibroblast), HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human, mouse
Enzymes shown to modify site in vitro
Type Enzyme
METHYLTRANSFERASE PRMT3 (mouse)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
METHYLTRANSFERASE PRMT3 (mouse) co-immunoprecipitation
Downstream Regulation
Effect of modification (function):  protein processing
Comments:  involved in ribosomal function and in the regulation of protein synthesis

R44-me - RPS2 (mouse)
Modsite: GrGrGrGrGrGrGAR SwissProt Entrez-Gene
Orthologous residues
RPS2 (human): R44‑me, RPS2 (mouse): R44‑me, RPS2 (rat): R44‑me
Characterization
Methods used to characterize site in vivo mutation of modification site, peptide sequencing, western blotting
Relevant cell lines - cell types - tissues:  3T3 (fibroblast), HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human, mouse
Enzymes shown to modify site in vitro
Type Enzyme
METHYLTRANSFERASE PRMT3 (mouse)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
METHYLTRANSFERASE PRMT3 (mouse) co-immunoprecipitation
Downstream Regulation
Effect of modification (function):  protein processing
Comments:  involved in ribosomal function and in the regulation of protein synthesis

R46-me - RPS2 (mouse)
Modsite: GrGrGrGrGrGARGG SwissProt Entrez-Gene
Orthologous residues
RPS2 (human): R46‑me, RPS2 (mouse): R46‑me, RPS2 (rat): R46‑me
Characterization
Methods used to characterize site in vivo mutation of modification site, peptide sequencing, western blotting
Relevant cell lines - cell types - tissues:  3T3 (fibroblast), HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human, mouse
Enzymes shown to modify site in vitro
Type Enzyme
METHYLTRANSFERASE PRMT3 (mouse)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
METHYLTRANSFERASE PRMT3 (mouse) co-immunoprecipitation
Downstream Regulation
Effect of modification (function):  protein processing
Comments:  involved in ribosomal function and in the regulation of protein synthesis

R48-me - RPS2 (mouse)
Modsite: GrGrGrGrGARGGKA SwissProt Entrez-Gene
Orthologous residues
RPS2 (human): R48‑me, RPS2 (mouse): R48‑me, RPS2 (rat): R48‑me
Characterization
Methods used to characterize site in vivo mutation of modification site, peptide sequencing, western blotting
Relevant cell lines - cell types - tissues:  3T3 (fibroblast), HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human, mouse
Enzymes shown to modify site in vitro
Type Enzyme
METHYLTRANSFERASE PRMT3 (mouse)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
METHYLTRANSFERASE PRMT3 (mouse) co-immunoprecipitation
Downstream Regulation
Effect of modification (function):  protein processing
Comments:  involved in ribosomal function and in the regulation of protein synthesis