Curated Information
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Home > Curated Information Page > PubMed Id: 18408713
Degterev A, et al. (2008) Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol 4, 313-21 18408713
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S6-p - RIPK1 (human)
Modsite: __MQPDMsLNVIKMk SwissProt Entrez-Gene
Orthologous residues
RIPK1 (human): S6‑p, RIPK1 iso2 (human): S6‑p, RIPK1 (mouse): S6‑p, RIPK1 (rat): S6‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, T cell leukemia
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

S14-p - RIPK1 (human)
Modsite: LNVIKMkssDFLEsA SwissProt Entrez-Gene
Orthologous residues
RIPK1 (human): S14‑p, RIPK1 iso2 (human): S14‑p, RIPK1 (mouse): S14‑p, RIPK1 (rat): S14‑p
Characterization
Methods used to characterize site in vivo mass spectrometry (in vitro)
Enzymes shown to modify site in vitro
Type Enzyme
KINASE RIPK1 (human)
Comments:  autophosphoryation

S15-p - RIPK1 (human)
Modsite: NVIKMkssDFLEsAE SwissProt Entrez-Gene
Orthologous residues
RIPK1 (human): S15‑p, RIPK1 iso2 (human): S15‑p, RIPK1 (mouse): S15‑p, RIPK1 (rat): D15‑p
Characterization
Methods used to characterize site in vivo mass spectrometry (in vitro)
Enzymes shown to modify site in vitro
Type Enzyme
KINASE RIPK1 (human)
Comments:  autophosphoryation

S20-p - RIPK1 (human)
Modsite: kssDFLEsAELDsGG SwissProt Entrez-Gene
Orthologous residues
RIPK1 (human): S20‑p, RIPK1 iso2 (human): S20‑p, RIPK1 (mouse): K20‑p, RIPK1 (rat): R20‑p
Characterization
Methods used to characterize site in vivo mass spectrometry (in vitro)
Enzymes shown to modify site in vitro
Type Enzyme
KINASE RIPK1 (human)
Comments:  autophosphoryation

S25-p - RIPK1 (human)
Modsite: LEsAELDsGGFGKVs SwissProt Entrez-Gene
Orthologous residues
RIPK1 (human): S25‑p, RIPK1 iso2 (human): S25‑p, RIPK1 (mouse): S25‑p, RIPK1 (rat): S25‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, T cell leukemia
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

S161-p - RIPK1 (human)
Modsite: IADLGLAsFkMWskL SwissProt Entrez-Gene
Orthologous residues
RIPK1 (human): S161‑p, RIPK1 iso2 (human): S115‑p, RIPK1 (mouse): S161‑p, RIPK1 (rat): S161‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, mass spectrometry (in vitro), mutation of modification site
Disease tissue studied:  leukemia, T cell leukemia
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE RIPK1 (human)
Comments:  autophosphoryation
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced
Comments:  necroptosis regulation

S166-p - RIPK1 (human)
Modsite: LAsFkMWskLNNEEH SwissProt Entrez-Gene
Orthologous residues
RIPK1 (human): S166‑p, RIPK1 iso2 (human): S120‑p, RIPK1 (mouse): S166‑p, RIPK1 (rat): S166‑p
Characterization
Methods used to characterize site in vivo mass spectrometry (in vitro)
Enzymes shown to modify site in vitro
Type Enzyme
KINASE RIPK1 (human)
Comments:  autophosphoryation

S303-p - RIPK1 (human)
Modsite: sVEEDVksLKkEYsN SwissProt Entrez-Gene
Orthologous residues
RIPK1 (human): S303‑p, RIPK1 iso2 (human): S257‑p, RIPK1 (mouse): S304‑p, RIPK1 (rat): S303‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, T cell leukemia
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

S320-p - RIPK1 (human)
Modsite: AVVkRMQsLQLdCVA SwissProt Entrez-Gene
Orthologous residues
RIPK1 (human): S320‑p, RIPK1 iso2 (human): S274‑p, RIPK1 (mouse): S321‑p, RIPK1 (rat): S320‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, T cell leukemia
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

S330-p - RIPK1 (human)
Modsite: LdCVAVPssRsNsAt SwissProt Entrez-Gene
Orthologous residues
RIPK1 (human): S330‑p, RIPK1 iso2 (human): S284‑p, RIPK1 (mouse): P331‑p, RIPK1 (rat): P330‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, T cell leukemia
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

S331-p - RIPK1 (human)
Modsite: dCVAVPssRsNsAtE SwissProt Entrez-Gene
Orthologous residues
RIPK1 (human): S331‑p, RIPK1 iso2 (human): S285‑p, RIPK1 (mouse): S332‑p, RIPK1 (rat): S331‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, T cell leukemia
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

S333-p - RIPK1 (human)
Modsite: VAVPssRsNsAtEQP SwissProt Entrez-Gene
Orthologous residues
RIPK1 (human): S333‑p, RIPK1 iso2 (human): S287‑p, RIPK1 (mouse): S334‑p, RIPK1 (rat): S333‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, T cell leukemia
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human