Mitra SS, Xu J, Nicholson BJ (2012) Coregulation of Multiple Signaling Mechanisms in pp60v-Src-Induced Closure of Cx43 Gap Junction Channels. J Membr Biol 245, 495-506 22965738

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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T185-p - ERK2 (human) ▲

Modsite: HDHtGFLtEyVAtRW SwissProt Entrez-Gene Orthologous residues ERK2 (human): T185‑p, ERK2 (mouse): T183‑p, ERK2 (rat): T183‑p, ERK2 (chicken): T193‑p, ERK2 (cow): T185‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Cellular systems studied:  primary cells Species studied:  frog Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes MEK1 (human) increase Src (human) increase PKCA (mouse) increase

Y187-p - ERK2 (human) ▲

Modsite: HtGFLtEyVAtRWyr SwissProt Entrez-Gene Orthologous residues ERK2 (human): Y187‑p, ERK2 (mouse): Y185‑p, ERK2 (rat): Y185‑p, ERK2 (chicken): Y195‑p, ERK2 (cow): Y187‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Cellular systems studied:  primary cells Species studied:  frog Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes MEK1 (human) increase Src (human) increase PKCA (mouse) increase

Y247-p - GJA1 (rat) ▲
Modsite: VKGRsDPyHATTGPL SwissProt Entrez-Gene Orthologous residues GJA1 (human): Y247‑p, GJA1 (mouse): Y247‑p, GJA1 (rat): Y247‑p, GJA1 (rabbit): Y247‑p, GJA1 (pig): Y247‑p, GJA1 (hamster): Y247‑p, GJA1 (cow): Y248‑p

S255-p - GJA1 (rat) ▲
Modsite: HATTGPLsPskDCGs SwissProt Entrez-Gene Orthologous residues GJA1 (human): S255‑p, GJA1 (mouse): S255‑p, GJA1 (rat): S255‑p, GJA1 (rabbit): S255‑p, GJA1 (pig): S255‑p, GJA1 (hamster): N255‑p, GJA1 (cow): S256‑p

S262-p - GJA1 (rat) ▲

Modsite: sPskDCGsPkyAyFN SwissProt Entrez-Gene Orthologous residues GJA1 (human): S262‑p, GJA1 (mouse): S262‑p, GJA1 (rat): S262‑p, GJA1 (rabbit): S262‑p, GJA1 (pig): S262‑p, GJA1 (hamster): S262‑p, GJA1 (cow): S263‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  oocyte Cellular systems studied:  primary cells Species studied:  frog

Y265-p - GJA1 (rat) ▲
Modsite: kDCGsPkyAyFNGCS SwissProt Entrez-Gene Orthologous residues GJA1 (human): Y265‑p, GJA1 (mouse): Y265‑p, GJA1 (rat): Y265‑p, GJA1 (rabbit): Y265‑p, GJA1 (pig): Y265‑p, GJA1 (hamster): Y265‑p, GJA1 (cow): Y266‑p

S279-p - GJA1 (rat) ▲
Modsite: SSPTAPLsPMsPPGY SwissProt Entrez-Gene Orthologous residues GJA1 (human): S279‑p, GJA1 (mouse): S279‑p, GJA1 (rat): S279‑p, GJA1 (rabbit): S279‑p, GJA1 (pig): S279‑p, GJA1 (hamster): S279‑p, GJA1 (cow): S280‑p

S282-p - GJA1 (rat) ▲
Modsite: TAPLsPMsPPGYkLV SwissProt Entrez-Gene Orthologous residues GJA1 (human): S282‑p, GJA1 (mouse): S282‑p, GJA1 (rat): S282‑p, GJA1 (rabbit): S282‑p, GJA1 (pig): S282‑p, GJA1 (hamster): S282‑p, GJA1 (cow): S283‑p

S297-p - GJA1 (rat) ▲

Modsite: TGDRNNssCRNYNkQ SwissProt Entrez-Gene Orthologous residues GJA1 (human): S297‑p, GJA1 (mouse): S297‑p, GJA1 (rat): S297‑p, GJA1 (rabbit): S297‑p, GJA1 (pig): S297‑p, GJA1 (hamster): S297‑p, GJA1 (cow): S298‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  oocyte Cellular systems studied:  primary cells Species studied:  frog Downstream Regulation Comments:  required for optimal CX43 function, but not Src gating response