Curated Information
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Home > Curated Information Page > PubMed Id: 22742832
Luo S, et al. (2012) Bim inhibits autophagy by recruiting beclin 1 to microtubules. Mol Cell 47, 359-70 22742832
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S104-p - BIM (human)
Modsite: FsFDTDRsPAPMSCD SwissProt Entrez-Gene
Orthologous residues
BIM (human): S104‑p, BIM iso2 (human): S44‑p, BIM iso3 (human): , BIM (mouse): S100‑p, BIM (rat): S100‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human

T116-p - BIM (human)
Modsite: SCDKsTQtPsPPCQA SwissProt Entrez-Gene
Orthologous residues
BIM (human): T116‑p, BIM iso2 (human): T56‑p, BIM iso3 (human): , BIM (mouse): T112‑p, BIM (rat): T112‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
starvation_medium increase
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  autophagy, induced
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
LC8 (human) Disrupts molecular association, regulation co-immunoprecipitation
beclin 1 (human) Disrupts co-immunoprecipitation

S118-p - BIM (human)
Modsite: DKsTQtPsPPCQAFN SwissProt Entrez-Gene
Orthologous residues
BIM (human): S118‑p, BIM iso2 (human): S58‑p, BIM iso3 (human): , BIM (mouse): S114‑p, BIM (rat): S114‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human