van Tiel CM, et al. (2012) Dual function of Pin1 in NR4A nuclear receptor activation: Enhanced activity of NR4As and increased Nur77 protein stability. Biochim Biophys Acta 1823, 1894-904 22789442

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S152-p - Nur77 (human) ▲

Modsite: SFQPPQLsPWDGSFG SwissProt Entrez-Gene Orthologous residues Nur77 (human): S152‑p, Nur77 iso2 (human): S165‑p, Nur77 (mouse): S154‑p, Nur77 (rat): S151‑p Characterization Methods used to characterize site in vivo:  immunoassay, mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE CK2A1 (human) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE CK2A1 (human) siRNA inhibition of enzyme, pharmacological inhibitor of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes TBB decrease siRNA decrease siRNA for CK2A decreases phosphorylation Downstream Regulation Effect of modification (function):  protein stabilization Comments:  Pin1 increases stability by acting on CK2 phosphorylated S152