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Home > Curated Information Page > PubMed Id: 22864830
Ma L, et al. (2012) p38α MAP kinase phosphorylates RCAN1 and regulates its interaction with calcineurin. Sci China Life Sci 55, 559-66 22864830
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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S146-p - RCAN1 (mouse)
Modsite: AQTLHIGsSHLAPPN SwissProt Entrez-Gene
Orthologous residues
RCAN1 (human): S148‑p, RCAN1 iso2 (human): S93‑p, RCAN1 iso3 (human): S67‑p, RCAN1 (mouse): S146‑p, RCAN1 (rat): S93‑p
Characterization
Methods used to characterize site in vivo mass spectrometry (in vitro)
Enzymes shown to modify site in vitro
Type Enzyme
KINASE P38A (human)
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PPP3CA (mouse) Disrupts enzymatic activity, induced in vitro

S161-p - RCAN1 (mouse)
Modsite: PDKQFLIsPPAsPPV SwissProt Entrez-Gene
Orthologous residues
RCAN1 (human): S163‑p, RCAN1 iso2 (human): S108‑p, RCAN1 iso3 (human): S82‑p, RCAN1 (mouse): S161‑p, RCAN1 (rat): S108‑p
Characterization
Methods used to characterize site in vivo mass spectrometry (in vitro)
Enzymes shown to modify site in vitro
Type Enzyme
KINASE P38A (human)
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PPP3CA (mouse) Disrupts enzymatic activity, induced in vitro

S165-p - RCAN1 (mouse)
Modsite: FLIsPPAsPPVGWKQ SwissProt Entrez-Gene
Orthologous residues
RCAN1 (human): S167‑p, RCAN1 iso2 (human): S112‑p, RCAN1 iso3 (human): S86‑p, RCAN1 (mouse): S165‑p, RCAN1 (rat): S112‑p
Characterization
Methods used to characterize site in vivo mass spectrometry (in vitro)
Enzymes shown to modify site in vitro
Type Enzyme
KINASE P38A (human)
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PPP3CA (mouse) Disrupts enzymatic activity, induced in vitro

T177-p - RCAN1 (mouse)
Modsite: WKQVEDAtPVINYDL SwissProt Entrez-Gene
Orthologous residues
RCAN1 (human): T179‑p, RCAN1 iso2 (human): T124‑p, RCAN1 iso3 (human): T98‑p, RCAN1 (mouse): T177‑p, RCAN1 (rat): T124‑p
Characterization
Methods used to characterize site in vivo mass spectrometry (in vitro)
Enzymes shown to modify site in vitro
Type Enzyme
KINASE P38A (human)
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PPP3CA (mouse) Disrupts enzymatic activity, induced in vitro

T206-p - RCAN1 (mouse)
Modsite: LHAATDTtPSVVVHV SwissProt Entrez-Gene
Orthologous residues
RCAN1 (human): T208‑p, RCAN1 iso2 (human): T153‑p, RCAN1 iso3 (human): T127‑p, RCAN1 (mouse): T206‑p, RCAN1 (rat): T153‑p
Characterization
Methods used to characterize site in vivo mass spectrometry (in vitro)
Enzymes shown to modify site in vitro
Type Enzyme
KINASE P38A (human)
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PPP3CA (mouse) Disrupts enzymatic activity, induced in vitro