Curated Information
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Home > Curated Information Page > PubMed Id: 22553040
Duan B, et al. (2012) PI3-kinase/Akt pathway-regulated membrane insertion of acid-sensing ion channel 1a underlies BDNF-induced pain hypersensitivity. J Neurosci 32, 6351-63 22553040
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S25-p - ASIC1 (human)
Modsite: IQAFASSsTLHGLAH SwissProt Entrez-Gene
Orthologous residues
ASIC1 (human): S25‑p, ASIC1 iso1 (human): S25‑p, ASIC1 iso3 (human): C71‑p, ASIC1 (mouse): S25‑p, ASIC1 (rat): S25‑p
Methods used to characterize site in vivo mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  CHO (fibroblast), neuron-spinal cord
Cellular systems studied:  cell lines, primary cells
Species studied:  green monkey, mouse, rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
BDNF increase
Downstream Regulation
Effect of modification (function):  activity, induced, intracellular localization
Effect of modification (process):  signaling pathway regulation
Comments:  increase the surface expression, pain hypersensitivity/ regulates BDNF-mediated mechanical hyperalgesia PI3K/Akt signaling pathway