Curated Information
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Home > Curated Information Page > PubMed Id: 22094462
Rey O, et al. (2012) Negative cross-talk between calcium-sensing receptor and β-catenin signaling systems in colonic epithelium. J Biol Chem 287, 1158-67 22094462
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S552-p - CTNNB1 (human)
Modsite: QDtQRRtsMGGtQQQ SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): S552‑p, CTNNB1 (mouse): S552‑p, CTNNB1 (rat): S552‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  NCMiCaSR (endothelial) [CaR (human), genetic knockin]
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Ca(2+) no change compared to control
Ca(2+) CaR (human) decrease
GSK690693 decrease
KT5720 decrease slight decrease
EGF increase
Ca(2+) EGF inhibit treatment-induced increase
tecalcet no change compared to control
tecalcet CaR (human) decrease
Downstream Regulation
Effect of modification (function):  intracellular localization
Comments:  nuclear localization, reduced phosphorylation -redistribution to plasma membrane

S675-p - CTNNB1 (human)
Modsite: QDykKRLsVELtsSL SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): S675‑p, CTNNB1 (mouse): S675‑p, CTNNB1 (rat): S675‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  NCMiCaSR (endothelial) [CaR (human), genetic knockin]
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Ca(2+) no change compared to control
Ca(2+) CaR (human) decrease
tecalcet no change compared to control
tecalcet CaR (human) decrease