Curated Information
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Home > Curated Information Page > PubMed Id: 22514276
Ashpole NM, et al. (2012) Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) Regulates Cardiac Sodium Channel NaV1.5 Gating by Multiple Phosphorylation Sites. J Biol Chem 287, 19856-69 22514276
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S516-p - SCN5A (human)
Modsite: LsLTrGLsRTsMKPR SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S516‑p, SCN5A (mouse): S516‑p, SCN5A (rat): S517‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CAMK2D (human)
KINASE CAMK2D (rat)
Downstream Regulation
Effect of modification (function):  activity, inhibited

T594-p - SCN5A (human)
Modsite: LHGkKNStVDCNGVV SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): T594‑p, SCN5A (mouse): T594‑p, SCN5A (rat): T595‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CAMK2D (human)
KINASE CAMK2D (rat)
Downstream Regulation
Effect of modification (function):  activity, inhibited