Curated Information
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Home > Curated Information Page > PubMed Id: 22511927
Du C, et al. (2012) Beta-catenin phosphorylated at threonine 120 antagonizes generation of active beta-catenin by spatial localization in trans-Golgi network. PLoS One 7, e33830 22511927
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S37-p - CTNNB1 (human)
Modsite: yLDsGIHsGATtTAP SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): S37‑p, CTNNB1 (mouse): S37‑p, CTNNB1 (rat): S37‑p, CTNNB1 (rabbit): S37‑p

T41-p - CTNNB1 (human)
Modsite: GIHsGATtTAPsLsG SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): T41‑p, CTNNB1 (mouse): T41‑p, CTNNB1 (rat): T41‑p, CTNNB1 (rabbit): T41‑p

T120-p - CTNNB1 (human)
Modsite: QFdAAHPtNVQRLAE SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): T120‑p, CTNNB1 (mouse): T120‑p, CTNNB1 (rat): T120‑p, CTNNB1 (rabbit): T120‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PRKD1 (human) siRNA inhibition of enzyme, pharmacological inhibitor of upstream enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CID755673 decrease
phosphorylated peptide decrease
siRNA decrease siRNA PKD1
Downstream Regulation
Effect of modification (function):  intracellular localization
Effect of modification (process):  transcription, inhibited
Associated Diseases
Diseases Alterations Comments
prostate cancer decreased