Du C, et al. (2012) Beta-catenin phosphorylated at threonine 120 antagonizes generation of active beta-catenin by spatial localization in trans-Golgi network. PLoS One 7, e33830 22511927

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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S37-p - CTNNB1 (human) ▲

Modsite: yLDsGIHsGATtTAP SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): S37‑p, CTNNB1 (mouse): S37‑p, CTNNB1 (rat): S37‑p, CTNNB1 (rabbit): S37‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Disease tissue studied:  prostate cancer Relevant cell lines - cell types - tissues:  C4-2 (prostate cell) Cellular systems studied:  cell lines Species studied:  human

T41-p - CTNNB1 (human) ▲

Modsite: GIHsGATtTAPsLsG SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): T41‑p, CTNNB1 (mouse): T41‑p, CTNNB1 (rat): T41‑p, CTNNB1 (rabbit): T41‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Disease tissue studied:  prostate cancer Relevant cell lines - cell types - tissues:  C4-2 (prostate cell) Cellular systems studied:  cell lines Species studied:  human

T120-p - CTNNB1 (human) ▲

Modsite: QFdAAHPtNVQRLAE SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): T120‑p, CTNNB1 (mouse): T120‑p, CTNNB1 (rat): T120‑p, CTNNB1 (rabbit): T120‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Disease tissue studied:  prostate cancer Relevant cell lines - cell types - tissues:  C4-2 (prostate cell), prostate Cellular systems studied:  cell lines, tissue Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PRKD1 (human) siRNA inhibition of enzyme, pharmacological inhibitor of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes CID755673 decrease phosphorylated peptide decrease siRNA decrease siRNA PKD1 Downstream Regulation Effect of modification (function):  intracellular localization Effect of modification (process):  transcription, inhibited Associated Diseases Diseases Alterations Comments prostate cancer decreased