Curated Information
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Home > Curated Information Page > PubMed Id: 8972483
Walter J, et al. (1996) The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum. Mol Med 2, 673-91 8972483
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S7-p - PSEN2 (human)
Modsite: _MLTFMAsDsEEEVC SwissProt Entrez-Gene
Orthologous residues
PSEN2 (human): S7‑p, PSEN2 (mouse): S7‑p, PSEN2 (rat): S7‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, peptide sequencing, phosphoamino acid analysis
Cellular systems studied:  cell lines
Species studied:  green monkey, hamster, human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK2A1 (human)

S9-p - PSEN2 (human)
Modsite: LTFMAsDsEEEVCDE SwissProt Entrez-Gene
Orthologous residues
PSEN2 (human): S9‑p, PSEN2 (mouse): S9‑p, PSEN2 (rat): S9‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, peptide sequencing, phosphoamino acid analysis
Cellular systems studied:  cell lines
Species studied:  green monkey, hamster, human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK2A1 (human)

S19-p - PSEN2 (human)
Modsite: EVCDERTsLMsAEsP SwissProt Entrez-Gene
Orthologous residues
PSEN2 (human): S19‑p, PSEN2 (mouse): S19‑p, PSEN2 (rat): S19‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, peptide sequencing, phosphoamino acid analysis
Cellular systems studied:  cell lines
Species studied:  green monkey, hamster, human