Curated Information
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Home > Curated Information Page > PubMed Id: 22473766
Singh M, Patel RC (2012) Increased interaction between PACT molecules in response to stress signals is required for PKR activation. J Cell Biochem 113, 2754-64 22473766
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S246-p - PACT (human)
Modsite: TDyIQLLsEIAKEQG SwissProt Entrez-Gene
Orthologous residues
PACT (human): S246‑p, PACT (mouse): S246‑p, PACT (rat): S246‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Cellular systems studied:  cell lines
Species studied:  yeast
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced, molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PACT (human) Induces yeast two-hybrid, co-immunoprecipitation

S287-p - PACT (human)
Modsite: PITVCHGsGISCGNA SwissProt Entrez-Gene
Orthologous residues
PACT (human): S287‑p, PACT (mouse): S287‑p, PACT (rat): S287‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Cellular systems studied:  cell lines
Species studied:  yeast
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
oxidative_stress increase
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced, molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PACT (human) Induces yeast two-hybrid, co-immunoprecipitation