Lee D, et al. (2012) Inositol 1,4,5-trisphosphate 3-kinase A is a novel microtubule-associated protein: PKA-dependent phosphoregulation of microtubule binding affinity. J Biol Chem 287, 15981-95 22389500

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S119-p - ITPKA (mouse) ▲

Modsite: LQQPRRLstSSLSST SwissProt Entrez-Gene Orthologous residues ITPKA (human): S121‑p, ITPKA (mouse): S119‑p, ITPKA (rat): S119‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  'neuron, hippocampal'-brain, 293 (epithelial), brain Cellular systems studied:  cell lines Species studied:  human, mouse, rat Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PKACA (human) transfection of inactive enzyme, transfection of wild-type enzyme, pharmacological inhibitor of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes H-89 NKH_477 inhibit treatment-induced increase NKH_477 increase Downstream Regulation Effect of modification (function):  molecular association, regulation Effect of modification (process):  cytoskeletal reorganization, neural plasticity Comments:  Phosphorylation at S119 inhibits the ITPKA and microtubule binding