Curated Information
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Home > Curated Information Page > PubMed Id: 12705864
Sordella R, et al. (2003) Modulation of Rho GTPase signaling regulates a switch between adipogenesis and myogenesis. Cell 113, 147-58 12705864
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y306-p - ARHGAP5 (human)
Modsite: NHPDYEEyINLEGTR SwissProt Entrez-Gene
Orthologous residues
ARHGAP5 (human): Y306‑p, ARHGAP5 iso2 (human): Y306‑p, ARHGAP5 (mouse): Y306‑p, ARHGAP5 iso3 (mouse): Y306‑p, ARHGAP5 (rat): Y305‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  3T3-L1 (fibroblast), C2C12 (myoblast), MEF (fibroblast)
Cellular systems studied:  cell lines
Species studied:  mouse
Enzymes shown to modify site in vitro
Type Enzyme
KINASE INSR (human)
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IGF-1 increase
Downstream Regulation
Effect of modification (function):  intracellular localization
Effect of modification (process):  cell differentiation, altered