Curated Information
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Home > Curated Information Page > PubMed Id: 12011079
Ahn S, et al. (2002) Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor. J Biol Chem 277, 26642-51 12011079
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y231-p - DYN1 (rat)
Modsite: LLPLRRGyIGVVNRS SwissProt Entrez-Gene
Orthologous residues
DYN1 (human): Y231‑p, DYN1 iso2 (human): Y231‑p, DYN1 iso3 (human): Y231‑p, DYN1 (mouse): Y231‑p, DYN1 iso3 (mouse): Y231‑p, DYN1 iso4 (mouse): Y231‑p, DYN1 iso6 (mouse): Y231‑p, DYN1 (rat): Y231‑p, DYN1 iso2 (rat): Y231‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody
Relevant cell lines - cell types - tissues:  COS (fibroblast)
Cellular systems studied:  cell lines
Species studied:  green monkey
Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGF increase
Downstream Regulation
Effect of modification (function):  molecular association, regulation, protein conformation
Comments:  Tyrosine phosphorylation promotes DYN1 self assembly.

Y354-p - DYN1 (rat)
Modsite: sGDQIDtyELSGGAR SwissProt Entrez-Gene
Orthologous residues
DYN1 (human): Y354‑p, DYN1 iso2 (human): Y354‑p, DYN1 iso3 (human): Y354‑p, DYN1 (mouse): Y354‑p, DYN1 iso3 (mouse): Y354‑p, DYN1 iso4 (mouse): Y354‑p, DYN1 iso6 (mouse): Y354‑p, DYN1 (rat): Y354‑p, DYN1 iso2 (rat): Y354‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody
Relevant cell lines - cell types - tissues:  COS (fibroblast)
Cellular systems studied:  cell lines
Species studied:  green monkey
Downstream Regulation
Effect of modification (function):  molecular association, regulation, protein conformation
Comments:  Tyrosine phosphorylation promotes DYN1 self assembly.

Y597-p - DYN1 (rat)
Modsite: NTEQRNVykDYRQLE SwissProt Entrez-Gene
Orthologous residues
DYN1 (human): Y597‑p, DYN1 iso2 (human): Y597‑p, DYN1 iso3 (human): Y597‑p, DYN1 (mouse): Y597‑p, DYN1 iso3 (mouse): Y597‑p, DYN1 iso4 (mouse): Y597‑p, DYN1 iso6 (mouse): Y593‑p, DYN1 (rat): Y597‑p, DYN1 iso2 (rat): Y597‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody
Relevant cell lines - cell types - tissues:  COS (fibroblast)
Cellular systems studied:  cell lines
Species studied:  green monkey
Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGF increase
Downstream Regulation
Effect of modification (function):  molecular association, regulation, protein conformation
Comments:  Tyrosine phosphorylation promotes DYN1 self assembly.