Curated Information
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Home > Curated Information Page > PubMed Id: 10373534
Ruffner H, et al. (1999) BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site. Mol Cell Biol 19, 4843-54 10373534
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S1497-p - BRCA1 (human)
Modsite: EPGVERssPsKCPsL SwissProt Entrez-Gene
Orthologous residues
BRCA1 (human): S1497‑p, BRCA1 iso6 (human): S393‑p, BRCA1 iso7 (human): S1518‑p, BRCA1 (mouse): S1454‑p, BRCA1 (rat): S1455‑p
Methods used to characterize site in vivo [32P] bio-synthetic labeling, immunoprecipitation, mass spectrometry, mutation of modification site, phosphopeptide mapping
Relevant cell lines - cell types - tissues:  HBL-100 (breast cell) [BRCA1 (human)], HBL-100 (breast cell) [CDK2 (human)]
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK2 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CDK2 (human) genetic transfer of wild-type enzyme
KINASE CDK2 (human) genetic transfer of dominant-negative enzyme