Curated Information
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Home > Curated Information Page > PubMed Id: 18390577
Hattori T, et al. (2008) Transcriptional regulation of chondrogenesis by coactivator Tip60 via chromatin association with Sox9 and Sox5. Nucleic Acids Res 36, 3011-24 18390577
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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K61-ac - SOX9 (human)
Modsite: PKGEPDLkKEsEEDk SwissProt Entrez-Gene
Orthologous residues
SOX9 (human): K61‑ac, SOX9 (mouse): K61‑ac, SOX9 (rat): K61‑ac, SOX9 (chicken): K61‑ac
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
ACETYLTRANSFERASE Tip60 (human) siRNA inhibition of enzyme, microscopy-colocalization, transfection of wild-type enzyme, co-immunoprecipitation Tip60 is a coactivator of Sox9 in chondrocytes.
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
siRNA decrease siRNA for Tip60 decreases acetylation

K253-ac - SOX9 (human)
Modsite: QPGkADLkREGRPLP SwissProt Entrez-Gene
Orthologous residues
SOX9 (human): K253‑ac, SOX9 (mouse): K253‑ac, SOX9 (rat): K253‑ac, SOX9 (chicken): K254‑ac
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
ACETYLTRANSFERASE Tip60 (human) siRNA inhibition of enzyme, microscopy-colocalization, transfection of wild-type enzyme, co-immunoprecipitation Tip60 is a coactivator of Sox9 in chondrocytes.
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
siRNA decrease siRNA for Tip60 decreases acetylation

K398-ac - SOX9 (human)
Modsite: QSQRTHIkTEQLSPS SwissProt Entrez-Gene
Orthologous residues
SOX9 (human): K398‑ac, SOX9 (mouse): K396‑ac, SOX9 (rat): K396‑ac, SOX9 (chicken): K376‑ac
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
ACETYLTRANSFERASE Tip60 (human) siRNA inhibition of enzyme, microscopy-colocalization, transfection of wild-type enzyme, co-immunoprecipitation Tip60 is a coactivator of Sox9 in chondrocytes.
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
siRNA decrease siRNA for Tip60 decreases acetylation