Curated Information
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Home > Curated Information Page > PubMed Id: 10995764
Besset V, Scott RP, Ibáñez CF (2000) Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase. J Biol Chem 275, 39159-66 10995764
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y1062-p - Ret (human)
Modsite: TWIENkLyGMsDPNW SwissProt Entrez-Gene
Orthologous residues
Ret (human): Y1062‑p, Ret iso2 (human): Y1062‑p, Ret iso3 (human): Y586‑p, Ret (mouse): Y1063‑p, Ret iso2 (mouse): Y1063‑p, Ret iso4 (mouse): , Ret (rat): Y1063‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  'neuron, superior cervical ganglion'-brain, 3T3 (fibroblast), MG87 (fibroblast)
Cellular systems studied:  cell lines, primary cells
Species studied:  mouse, rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
GDNF increase
Downstream Regulation
Effect of modification (function):  molecular association, regulation, phosphorylation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PIK3R1 (human) Induces pull-down assay
SHC1 (human) Induces phosphorylation co-immunoprecipitation
Comments:  regulates ERK phosphorylation/activation

Y1096-p - Ret (human)
Modsite: RyPNDSVyANWMLSP SwissProt Entrez-Gene
Orthologous residues
Ret (human): Y1096‑p, Ret iso2 (human): , Ret iso3 (human): , Ret (mouse): Y1097‑p, Ret iso2 (mouse): , Ret iso4 (mouse): , Ret (rat): Y1097‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  'neuron, superior cervical ganglion'-brain, 3T3 (fibroblast), MG87 (fibroblast)
Cellular systems studied:  cell lines, primary cells
Species studied:  mouse, rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
GDNF increase
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PIK3R1 (human) Induces pull-down assay
GRB2 (human) Induces pull-down assay