Abdelmohsen K, et al. (2003) Epidermal growth factor receptor is a common mediator of quinone-induced signaling leading to phosphorylation of connexin-43: role of glutathione and tyrosine phosphatases. J Biol Chem 278, 38360-7 12874275

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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S473-p - Akt1 (human) ▲

Modsite: RPHFPQFsYSASGTA SwissProt Entrez-Gene Orthologous residues Akt1 (human): S473‑p, Akt1 iso2 (human): S411‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes menadione increase DMNQ augment treatment-induced decrease BQ increase wortmannin BQ, DMNQ, menadione inhibit treatment-induced increase LY294002 BQ, DMNQ, menadione inhibit treatment-induced increase

T202-p - ERK1 (human) ▲

Modsite: HDHTGFLtEYVATRW SwissProt Entrez-Gene Orthologous residues ERK1 (human): T202‑p, ERK1 iso2 (human): T202‑p, ERK1 iso3 (human): T202‑p, ERK1 (mouse): T203‑p, ERK1 (rat): T203‑p, ERK1 (hamster): T192‑p Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes BQ increase DMNQ increase menadione increase U0126 BQ, DMNQ inhibit treatment-induced increase U0126 menadione no change compared to control AG1478 BQ, DMNQ, menadione inhibit treatment-induced increase EGF increase menadione EGF augment treatment-induced decrease

Y204-p - ERK1 (human) ▲

Modsite: HTGFLTEyVATRWYR SwissProt Entrez-Gene Orthologous residues ERK1 (human): Y204‑p, ERK1 iso2 (human): Y204‑p, ERK1 iso3 (human): Y204‑p, ERK1 (mouse): Y205‑p, ERK1 (rat): Y205‑p, ERK1 (hamster): Y194‑p Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes BQ increase DMNQ increase menadione increase U0126 BQ, DMNQ inhibit treatment-induced increase U0126 menadione no change compared to control AG1478 BQ, DMNQ, menadione inhibit treatment-induced increase EGF increase menadione EGF augment treatment-induced decrease

T185-p - ERK2 (human) ▲

Modsite: HDHTGFLtEYVATRW SwissProt Entrez-Gene Orthologous residues ERK2 (human): T185‑p, ERK2 (mouse): T183‑p, ERK2 (rat): T183‑p, ERK2 (chicken): T193‑p, ERK2 (cow): T185‑p Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes BQ increase DMNQ increase menadione increase U0126 BQ, DMNQ inhibit treatment-induced increase U0126 menadione no change compared to control AG1478 BQ, DMNQ, menadione inhibit treatment-induced increase EGF increase menadione EGF augment treatment-induced decrease

Y187-p - ERK2 (human) ▲

Modsite: HTGFLTEyVATRWYR SwissProt Entrez-Gene Orthologous residues ERK2 (human): Y187‑p, ERK2 (mouse): Y185‑p, ERK2 (rat): Y185‑p, ERK2 (chicken): Y195‑p, ERK2 (cow): Y187‑p Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes BQ increase DMNQ increase menadione increase U0126 BQ, DMNQ inhibit treatment-induced increase U0126 menadione no change compared to control AG1478 BQ, DMNQ, menadione inhibit treatment-induced increase EGF increase menadione EGF augment treatment-induced decrease

S279-p - GJA1 (rat) ▲

Modsite: SSPTAPLsPMSPPGY SwissProt Entrez-Gene Orthologous residues GJA1 (human): S279‑p, GJA1 (mouse): S279‑p, GJA1 (rat): S279‑p, GJA1 (rabbit): S279‑p, GJA1 (pig): S279‑p, GJA1 (hamster): S279‑p, GJA1 (cow): S280‑p Characterization Methods used to characterize site in vivo:  phospho-antibody Relevant cell lines - cell types - tissues:  WB-F344 (epithelial) Cellular systems studied:  cell lines Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes BQ increase DMNQ increase DEM increase menadione increase

S282-p - GJA1 (rat) ▲

Modsite: TAPLSPMsPPGYKLV SwissProt Entrez-Gene Orthologous residues GJA1 (human): S282‑p, GJA1 (mouse): S282‑p, GJA1 (rat): S282‑p, GJA1 (rabbit): S282‑p, GJA1 (pig): S282‑p, GJA1 (hamster): S282‑p, GJA1 (cow): S283‑p Characterization Methods used to characterize site in vivo:  phospho-antibody Relevant cell lines - cell types - tissues:  WB-F344 (epithelial) Cellular systems studied:  cell lines Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes BQ increase DMNQ increase DEM increase menadione increase