Curated Information
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Home > Curated Information Page > PubMed Id: 28869759
Saadipour K, et al. (2018) p75 neurotrophin receptor interacts with and promotes BACE1 localization in endosomes aggravating amyloidogenesis. J Neurochem 144, 302-317 28869759
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T668-p - APP iso2 (mouse)
Modsite: VEVDAAVtPEERHLS SwissProt Entrez-Gene
Orthologous residues
APP (human): T743‑p, APP iso4 (human): T668‑p, APP iso8 (human): T724‑p, APP iso10 (human): T612‑p, APP (mouse): T743‑p, APP iso2 (mouse): T668‑p, APP (rat): T743‑p, APP iso2 (rat): T668‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'neuron, cortical'
Cellular systems studied:  primary cultured cells
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
beta-amyloid_42 NGFR (mouse) increase
beta-amyloid_42 NGFR (mouse) increase
SP600125 beta-amyloid_42 NGFR (mouse) inhibit treatment-induced increase

S498-p - BACE (mouse)
Modsite: DDFADDIsLLK____ SwissProt Entrez-Gene
Orthologous residues
BACE (human): S498‑p, BACE (mouse): S498‑p, BACE (rat): S498‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'neuron, cortical'
Cellular systems studied:  primary cultured cells
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
beta-amyloid_42 NGFR (mouse) increase