Xiao JY, Liu C, Sun XH, Yu BZ (2012) [PKA-regulated phosphorylation status of S149 and S321 sites of CDC25B inhibits mitosis of fertilized mouse eggs]. Sheng Li Xue Bao 64, 33-40 22348958

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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S149-p - CDC25B (mouse) ▲

Modsite: FTIKRFRsLPVRLLE SwissProt Entrez-Gene Orthologous residues CDC25B (human): S151‑p, CDC25B iso2 (human): S137‑p, CDC25B iso3 (human): S151‑p, CDC25B (mouse): S149‑p, CDC25B (rat): S151‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  oocyte Cellular systems studied:  primary cultured cells Species studied:  mouse Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PKACA (mouse) pharmacological inhibitor of upstream enzyme Downstream Regulation Effect of modification (process):  cell cycle regulation

S321-p - CDC25B (mouse) ▲

Modsite: QRLFRsPsMPCSVIR SwissProt Entrez-Gene Orthologous residues CDC25B (human): S323‑p, CDC25B iso2 (human): S309‑p, CDC25B iso3 (human): S282‑p, CDC25B (mouse): S321‑p, CDC25B (rat): S319‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  oocyte Cellular systems studied:  primary cultured cells Species studied:  mouse Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PKACA (mouse) pharmacological inhibitor of upstream enzyme Downstream Regulation Effect of modification (process):  cell cycle regulation

Y15-p - CDK1 (mouse) ▲

Modsite: EKIGEGtyGVVyKGR SwissProt Entrez-Gene Orthologous residues CDK1 (human): Y15‑p, CDK1 iso2 (human): Y15‑p, CDK1 (mouse): Y15‑p, CDK1 (rat): Y15‑p, CDK1 (chicken): Y15‑p, CDK1 (fruit fly): Y15‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  oocyte Cellular systems studied:  primary cultured cells Species studied:  mouse