Curated Information
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Home > Curated Information Page > PubMed Id: 16644734
Lehmann IT, et al. (2006) Differential regulation of the human tyrosine hydroxylase isoforms via hierarchical phosphorylation. J Biol Chem 281, 17644-51 16644734
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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S62-p - TH (human)
Modsite: SYTPTPRsPRFIGRR SwissProt Entrez-Gene
Orthologous residues
TH (human): S62‑p, TH iso2 (human): S58‑p, TH iso3 (human): S31‑p, TH iso4 (human): S35‑p, TH (mouse): S31‑p, TH (rat): S31‑p, TH (cow): S31‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE ERK2 (human)

S71-p - TH (human)
Modsite: RFIGRRQsLIEDARK SwissProt Entrez-Gene
Orthologous residues
TH (human): S71‑p, TH iso2 (human): S67‑p, TH iso3 (human): S40‑p, TH iso4 (human): S44‑p, TH (mouse): S40‑p, TH (rat): S40‑p, TH (cow): S40‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKACA (human)

S58-p - TH iso2 (human)
Modsite: SYTPTPRsPRFIGRR SwissProt Entrez-Gene
Orthologous residues
TH (human): S62‑p, TH iso2 (human): S58‑p, TH iso3 (human): S31‑p, TH iso4 (human): S35‑p, TH (mouse): S31‑p, TH (rat): S31‑p, TH (cow): S31‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE ERK2 (human)

S67-p - TH iso2 (human)
Modsite: RFIGRRQsLIEDARK SwissProt Entrez-Gene
Orthologous residues
TH (human): S71‑p, TH iso2 (human): S67‑p, TH iso3 (human): S40‑p, TH iso4 (human): S44‑p, TH (mouse): S40‑p, TH (rat): S40‑p, TH (cow): S40‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKACA (human)

S31-p - TH iso3 (human)
Modsite: KQAEAIMsPRFIGRR SwissProt Entrez-Gene
Orthologous residues
TH (human): S62‑p, TH iso2 (human): S58‑p, TH iso3 (human): S31‑p, TH iso4 (human): S35‑p, TH (mouse): S31‑p, TH (rat): S31‑p, TH (cow): S31‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE ERK2 (human)

S40-p - TH iso3 (human)
Modsite: RFIGRRQsLIEDARK SwissProt Entrez-Gene
Orthologous residues
TH (human): S71‑p, TH iso2 (human): S67‑p, TH iso3 (human): S40‑p, TH iso4 (human): S44‑p, TH (mouse): S40‑p, TH (rat): S40‑p, TH (cow): S40‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKACA (human)
KINASE CAMK2A (human)

S44-p - TH iso4 (human)
Modsite: RFIGRRQsLIEDARK SwissProt Entrez-Gene
Orthologous residues
TH (human): S71‑p, TH iso2 (human): S67‑p, TH iso3 (human): S40‑p, TH iso4 (human): S44‑p, TH (mouse): S40‑p, TH (rat): S40‑p, TH (cow): S40‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CAMK2A (human)

S31-p - TH (rat)
Modsite: KQAEAVTsPRFIGRR SwissProt Entrez-Gene
Orthologous residues
TH (human): S62‑p, TH iso2 (human): S58‑p, TH iso3 (human): S31‑p, TH iso4 (human): S35‑p, TH (mouse): S31‑p, TH (rat): S31‑p, TH (cow): S31‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE ERK2 (human)

S40-p - TH (rat)
Modsite: RFIGRRQsLIEDARK SwissProt Entrez-Gene
Orthologous residues
TH (human): S71‑p, TH iso2 (human): S67‑p, TH iso3 (human): S40‑p, TH iso4 (human): S44‑p, TH (mouse): S40‑p, TH (rat): S40‑p, TH (cow): S40‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKACA (human)

S31-p - TH (cow)
Modsite: KQAEAIMsPRFVGRR SwissProt Entrez-Gene
Orthologous residues
TH (human): S62‑p, TH iso2 (human): S58‑p, TH iso3 (human): S31‑p, TH iso4 (human): S35‑p, TH (mouse): S31‑p, TH (rat): S31‑p, TH (cow): S31‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
angiotensin_2 augment treatment-induced decrease
colforsin angiotensin_2 no effect upon treatment-induced increase
colforsin no change compared to control

S40-p - TH (cow)
Modsite: RFVGRRQsLIQDARK SwissProt Entrez-Gene
Orthologous residues
TH (human): S71‑p, TH iso2 (human): S67‑p, TH iso3 (human): S40‑p, TH iso4 (human): S44‑p, TH (mouse): S40‑p, TH (rat): S40‑p, TH (cow): S40‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
angiotensin_2 no change compared to control
colforsin increase
angiotensin_2 colforsin augment treatment-induced increase