Curated Information
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Home > Curated Information Page > PubMed Id: 28882890
Burel S, et al. (2017) C-terminal phosphorylation of NaV1.5 impairs FGF13-dependent regulation of channel inactivation. J Biol Chem 292, 17431-17448 28882890
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S1934-p - SCN5A (human)
Modsite: LFRQQAGsGLsEEDA SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S1934‑p, SCN5A (mouse): S1936‑p, SCN5A (rat): G1936‑p
Downstream Regulation
Effect of modification (function):  activity, induced, molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Calmodulin (mouse) Disrupts co-immunoprecipitation
FGF13 (mouse) Disrupts co-immunoprecipitation
Comments:  impairs FGF13-dependent regulation of NaV1.5 channel inactivation

S1985-p - SCN5A (human)
Modsite: DSVTRATsDNLQVRG SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S1985‑p, SCN5A (mouse): S1988‑p, SCN5A (rat): S1988‑p
Downstream Regulation
Effect of modification (function):  activity, induced, molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
FGF13 (mouse) Disrupts co-immunoprecipitation
Calmodulin (mouse) Disrupts co-immunoprecipitation
Comments:  impairs FGF13-dependent regulation of NaV1.5 channel inactivation

S36-p - SCN5A (mouse)
Modsite: AEKQARGsAtsQEsR SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S36‑p, SCN5A (mouse): S36‑p, SCN5A (rat): S37‑p

T38-p - SCN5A (mouse)
Modsite: KQARGsAtsQEsREG SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): T38‑p, SCN5A (mouse): T38‑p, SCN5A (rat): T39‑p

S39-p - SCN5A (mouse)
Modsite: QARGsAtsQEsREGL SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): L39‑p, SCN5A (mouse): S39‑p, SCN5A (rat): S40‑p

S42-p - SCN5A (mouse)
Modsite: GsAtsQEsREGLPEE SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S42‑p, SCN5A (mouse): S42‑p, SCN5A (rat): S43‑p

S457-p - SCN5A (mouse)
Modsite: IRGVDTVsRssLEMS SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S457‑p, SCN5A (mouse): S457‑p, SCN5A (rat): S458‑p

S460-p - SCN5A (mouse)
Modsite: VDTVsRssLEMSPLA SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S460‑p, SCN5A (mouse): S460‑p, SCN5A (rat): S461‑p

S483-p - SCN5A (mouse)
Modsite: SKRRKRLssGtEDGG SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S483‑p, SCN5A (mouse): S483‑p, SCN5A (rat): S484‑p

S484-p - SCN5A (mouse)
Modsite: KRRKRLssGtEDGGD SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S484‑p, SCN5A (mouse): S484‑p, SCN5A (rat): S485‑p

T486-p - SCN5A (mouse)
Modsite: RKRLssGtEDGGDDR SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): T486‑p, SCN5A (mouse): T486‑p, SCN5A (rat): T487‑p

S497-p - SCN5A (mouse)
Modsite: GDDRLPKsDsEDGPR SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S497‑p, SCN5A (mouse): S497‑p, SCN5A (rat): S498‑p

S499-p - SCN5A (mouse)
Modsite: DRLPKsDsEDGPRAL SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S499‑p, SCN5A (mouse): S499‑p, SCN5A (rat): S500‑p

S510-p - SCN5A (mouse)
Modsite: PRALNQLsLTHGLsR SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S510‑p, SCN5A (mouse): S510‑p, SCN5A (rat): S511‑p

S516-p - SCN5A (mouse)
Modsite: LsLTHGLsRTSMRPR SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S516‑p, SCN5A (mouse): S516‑p, SCN5A (rat): S517‑p

S524-p - SCN5A (mouse)
Modsite: RTSMRPRssrGsIFT SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S524‑p, SCN5A (mouse): S524‑p, SCN5A (rat): S525‑p

S525-p - SCN5A (mouse)
Modsite: TSMRPRssrGsIFTF SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S525‑p, SCN5A (mouse): S525‑p, SCN5A (rat): S526‑p

S539-p - SCN5A (mouse)
Modsite: FRRRDQGsEADFADD SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S539‑p, SCN5A (mouse): S539‑p, SCN5A (rat): S540‑p

S571-p - SCN5A (mouse)
Modsite: PWPLRRPsTQGQPGF SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S571‑p, SCN5A (mouse): S571‑p, SCN5A (rat): S572‑p

S664-p - SCN5A (mouse)
Modsite: GARQRALsAVsVLts SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S664‑p, SCN5A (mouse): S664‑p, SCN5A (rat): S665‑p

S1012-p - SCN5A (mouse)
Modsite: sCIAAPRsPPPPEVE SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S1010‑p, SCN5A (mouse): S1012‑p, SCN5A (rat): S1013‑p

S1887-p - SCN5A (mouse)
Modsite: KFMAANPsKISYEPI SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S1885‑p, SCN5A (mouse): S1887‑p, SCN5A (rat): S1887‑p

S1936-p - SCN5A (mouse)
Modsite: LFRQQAGssGLSDED SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S1934‑p, SCN5A (mouse): S1936‑p, SCN5A (rat): G1936‑p

S1937-p - SCN5A (mouse)
Modsite: FRQQAGssGLSDEDA SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): , SCN5A (mouse): S1937‑p, SCN5A (rat): S1937‑p
Downstream Regulation
Effect of modification (function):  activity, induced, molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Calmodulin (mouse) Disrupts co-immunoprecipitation
FGF13 (mouse) Disrupts co-immunoprecipitation
Comments:  impairs FGF13-dependent regulation of NaV1.5 channel inactivation

S1988-p - SCN5A (mouse)
Modsite: DSVTRATsDNLPVRA SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S1985‑p, SCN5A (mouse): S1988‑p, SCN5A (rat): S1988‑p
Downstream Regulation
Effect of modification (function):  activity, induced, molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Calmodulin (mouse) Disrupts co-immunoprecipitation
FGF13 (mouse) Disrupts co-immunoprecipitation
Comments:  impairs FGF13-dependent regulation of NaV1.5 channel inactivation