Curated Information
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Home > Curated Information Page > PubMed Id: 22222486
Andersen SD, et al. (2012) 14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif. DNA Repair (Amst) 11, 267-77 22222486
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S746-p - EXO1 (human)
Modsite: PGLYkSSsADsLStT SwissProt Entrez-Gene
Orthologous residues
EXO1 (human): S746‑p, EXO1 (mouse): S737‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  3T3 (fibroblast), HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human, mouse
Downstream Regulation
Effect of modification (function):  molecular association, regulation, protein conformation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
14-3-3 gamma (human) Induces pull-down assay
14-3-3 sigma (human) Induces pull-down assay
14-3-3 eta (human) Induces pull-down assay
14-3-3 beta (human) Induces pull-down assay