Curated Information
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Home > Curated Information Page > PubMed Id: 22250817
Davis MM, et al. (2012) Regulator of calmodulin signaling knockout mice display anxiety-like behavior and motivational deficits. Eur J Neurosci 35, 300-8 22250817
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T34-p - DARPP-32 (mouse)
Modsite: MIRRRRPtPAMLFRV SwissProt Entrez-Gene
Orthologous residues
DARPP‑32 (human): T34‑p, DARPP‑32 iso2 (human): , DARPP‑32 (mouse): T34‑p, DARPP‑32 (rat): T34‑p, DARPP‑32 (cow): T34‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'brain, amygdala', 'brain, hippocampus', 'brain, striatum'
Cellular systems studied:  tissue
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ARPP-21 (mouse) no change compared to control no change in striatum homogenetes of APP-21 KO mice

S863-p - GluR1 (mouse)
Modsite: tstLPRNsGAGASGG SwissProt Entrez-Gene
Orthologous residues
GluR1 (human): S863‑p, GluR1 iso6 (human): S873‑p, GluR1 (mouse): S863‑p, GluR1 (rat): S863‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'brain, amygdala', 'brain, hippocampus', 'brain, striatum'
Cellular systems studied:  tissue
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ARPP-21 (mouse) no change compared to control no change in amygdala, striatum and hippocampal homogenates of ARPP-21 KO mice

S9-p - SYN1 (mouse)
Modsite: NYLRRRLsDsNFMAN SwissProt Entrez-Gene
Orthologous residues
SYN1 (human): S9‑p, SYN1 iso2 (human): S9‑p, SYN1 (mouse): S9‑p, SYN1 iso1 (mouse): S9‑p, SYN1 iso3 (mouse): S9‑p, SYN1 (rat): S9‑p, SYN1 (cow): S9‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'brain, amygdala', 'brain, hippocampus', 'brain, striatum'
Cellular systems studied:  tissue
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ARPP-21 (mouse) no change compared to control no change in amygdala, striatum and hippocampal homogenates of ARPP-21 KO mice

S62-p - SYN1 (mouse)
Modsite: stAAPVAsPAAPsPG SwissProt Entrez-Gene
Orthologous residues
SYN1 (human): S62‑p, SYN1 iso2 (human): S62‑p, SYN1 (mouse): S62‑p, SYN1 iso1 (mouse): S62‑p, SYN1 iso3 (mouse): S62‑p, SYN1 (rat): S62‑p, SYN1 (cow): S62‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'brain, amygdala', 'brain, hippocampus', 'brain, striatum'
Cellular systems studied:  tissue
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ARPP-21 (mouse) decrease decreased in striatal homogenates of ARPP-21 KO mice
ARPP-21 (mouse) no change compared to control no change in amygdala and hippocampal homogenates of ARPP-21 KO mice

S67-p - SYN1 (mouse)
Modsite: VAsPAAPsPGssGGG SwissProt Entrez-Gene
Orthologous residues
SYN1 (human): S67‑p, SYN1 iso2 (human): S67‑p, SYN1 (mouse): S67‑p, SYN1 iso1 (mouse): S67‑p, SYN1 iso3 (mouse): S67‑p, SYN1 (rat): S67‑p, SYN1 (cow): S67‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'brain, amygdala', 'brain, hippocampus', 'brain, striatum'
Cellular systems studied:  tissue
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ARPP-21 (mouse) decrease decreased in striatal homogenates of ARPP-21 KO mice
ARPP-21 (mouse) no change compared to control no change in amygdala and hippocampal homogenates of ARPP-21 KO mice