Curated Information
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Home > Curated Information Page > PubMed Id: 22265413
Sun L, et al. (2012) Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 148, 213-27 22265413
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T357-p - MLKL (human)
Modsite: FELRkTQtsMSLGTt SwissProt Entrez-Gene
Orthologous residues
MLKL (human): T357‑p, MLKL (mouse): N344‑p, MLKL (rat): T344‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE RIPK3 (human)

S358-p - MLKL (human)
Modsite: ELRkTQtsMSLGTtR SwissProt Entrez-Gene
Orthologous residues
MLKL (human): S358‑p, MLKL (mouse): S345‑p, MLKL (rat): S345‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE RIPK3 (human)

S227-p - RIPK3 (human)
Modsite: VELPtEPsLVYEAVC SwissProt Entrez-Gene
Orthologous residues
RIPK3 (human): S227‑p, RIPK3 (mouse): S232‑p, RIPK3 (rat): S229‑p

S232-p - RIPK3 (mouse)
Modsite: AELVDKtsLIRETVC SwissProt Entrez-Gene
Orthologous residues
RIPK3 (human): S227‑p, RIPK3 (mouse): S232‑p, RIPK3 (rat): S229‑p