Curated Information
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Home > Curated Information Page > PubMed Id: 20353941
Coultrap SJ, et al. (2010) CaMKII autonomy is substrate-dependent and further stimulated by Ca2+/calmodulin. J Biol Chem 285, 17930-7 20353941
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T286-p - CAMK2A (human)
Modsite: SCMHRQEtVDCLKKF SwissProt Entrez-Gene
Orthologous residues
CAMK2A (human): T286‑p, CAMK2A iso2 (human): T286‑p, CAMK2A (mouse): T286‑p, CAMK2A iso2 (mouse): , CAMK2A (rat): T286‑p

T305-p - CAMK2A (human)
Modsite: kLkGAILttMLAtRN SwissProt Entrez-Gene
Orthologous residues
CAMK2A (human): T305‑p, CAMK2A iso2 (human): T305‑p, CAMK2A (mouse): T305‑p, CAMK2A iso2 (mouse): , CAMK2A (rat): T305‑p

T306-p - CAMK2A (human)
Modsite: LkGAILttMLAtRNF SwissProt Entrez-Gene
Orthologous residues
CAMK2A (human): T306‑p, CAMK2A iso2 (human): T306‑p, CAMK2A (mouse): T306‑p, CAMK2A iso2 (mouse): , CAMK2A (rat): T306‑p

S849-p - GluR1 (human)
Modsite: FCLIPQQsINEAIRT SwissProt Entrez-Gene
Orthologous residues
GluR1 (human): S849‑p, GluR1 iso6 (human): S859‑p, GluR1 (mouse): S849‑p, GluR1 (rat): S849‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionomycin decrease

S1303-p - NMDAR2B (human)
Modsite: NKLRRQHsyDtFVDL SwissProt Entrez-Gene
Orthologous residues
NMDAR2B (human): S1303‑p, NMDAR2B (mouse): S1303‑p, NMDAR2B (rat): S1303‑p

S19-p - TH (rat)
Modsite: KGFRRAVsEQDAKQA SwissProt Entrez-Gene
Orthologous residues
TH (human): S19‑p, TH iso2 (human): S19‑p, TH iso3 (human): S19‑p, TH iso4 (human): S19‑p, TH (mouse): S19‑p, TH (rat): S19‑p, TH (cow): S19‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  adrenal cancer, pheochromocytoma
Relevant cell lines - cell types - tissues:  PC-12 (chromaffin)
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
depolarization increase