Curated Information
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Home > Curated Information Page > PubMed Id: 20190034
Deng H, et al. (2010) Pulmonary artery smooth muscle hypertrophy: roles of glycogen synthase kinase-3beta and p70 ribosomal S6 kinase. Am J Physiol Lung Cell Mol Physiol 298, L793-803 20190034
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S540-p - eIF2B-epsilon (human)
Modsite: MDsEEPDsRGGsPQM SwissProt Entrez-Gene
Orthologous residues
eIF2B‑epsilon (human): S540‑p, eIF2B‑epsilon (mouse): S536‑p, eIF2B‑epsilon (rat): S535‑p, eIF2B‑epsilon (rabbit): S540‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, smooth'-'heart, artery', A7r5 ('muscle, smooth')
Cellular systems studied:  cell lines, tissue
Species studied:  human, rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
BMP4 no change compared to control
TGF-beta no change compared to control
5-HT no change compared to control
endothelin no change compared to control
lithium decrease
SB216763 decrease

S9-p - GSK3B (human)
Modsite: SGRPRttsFAEsCkP SwissProt Entrez-Gene
Orthologous residues
GSK3B (human): S9‑p, GSK3B iso2 (human): S9‑p, GSK3B (mouse): S9‑p, GSK3B (rat): S9‑p, GSK3B (rabbit): S9‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, smooth'-'heart, artery', A7r5 ('muscle, smooth')
Cellular systems studied:  cell lines, tissue
Species studied:  human, rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
BMP4 increase
TGF-beta increase
5-HT increase
endothelin increase
lithium increase
SB216763 no change compared to control

T412-p - p70S6K (human)
Modsite: NQVFLGFtyVAPsVL SwissProt Entrez-Gene
Orthologous residues
p70S6K (human): T412‑p, p70S6K iso2 (human): T389‑p, p70S6K (mouse): T412‑p, p70S6K (rat): T412‑p, p70S6K iso2 (rat): T389‑p, p70S6K (fruit fly): T398‑p
Associated Diseases
Diseases Alterations Comments
hypertrophic cardiomyopathy increased