Curated Information
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Home > Curated Information Page > PubMed Id: 20008839
Yoshizawa A, et al. (2010) Overexpression of phospho-eIF4E is associated with survival through AKT pathway in non-small cell lung cancer. Clin Cancer Res 16, 240-8 20008839
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S473-p - Akt1 (human)
Modsite: RPHFPQFsysAsGtA SwissProt Entrez-Gene
Orthologous residues
Akt1 (human): S473‑p, Akt1 iso2 (human): S411‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  lung
Cellular systems studied:  tissue
Species studied:  human
Downstream Regulation
Effect of modification (function):  activity, induced, enzymatic activity, induced
Comments:  eIF4E activation through the AKT pathway leads to progression in NSCLC
Associated Diseases
Diseases Alterations Comments
non-small cell squamous cell lung carcinoma increased predicts poor prognosis

S209-p - EIF4E (human)
Modsite: DtATksGsttKNRFV SwissProt Entrez-Gene
Orthologous residues
EIF4E (human): S209‑p, EIF4E iso2 (human): S240‑p, EIF4E (mouse): S209‑p, EIF4E (rat): S209‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  lung
Cellular systems studied:  tissue
Species studied:  human
Downstream Regulation
Effect of modification (function):  activity, induced, enzymatic activity, induced
Comments:  eIF4E activation through the AKT pathway leads to progression in NSCLC
Associated Diseases
Diseases Alterations Comments
non-small cell squamous cell lung carcinoma increased predicts poor prognosis

T202-p - ERK1 (human)
Modsite: HDHtGFLtEyVAtRW SwissProt Entrez-Gene
Orthologous residues
ERK1 (human): T202‑p, ERK1 iso2 (human): T202‑p, ERK1 iso3 (human): T202‑p, ERK1 (mouse): T203‑p, ERK1 (rat): T203‑p, ERK1 (hamster): T192‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  lung
Cellular systems studied:  tissue
Species studied:  human

Y204-p - ERK1 (human)
Modsite: HtGFLtEyVAtRWyr SwissProt Entrez-Gene
Orthologous residues
ERK1 (human): Y204‑p, ERK1 iso2 (human): Y204‑p, ERK1 iso3 (human): Y204‑p, ERK1 (mouse): Y205‑p, ERK1 (rat): Y205‑p, ERK1 (hamster): Y194‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  lung
Cellular systems studied:  tissue
Species studied:  human

T185-p - ERK2 (human)
Modsite: HDHtGFLtEyVAtRW SwissProt Entrez-Gene
Orthologous residues
ERK2 (human): T185‑p, ERK2 (mouse): T183‑p, ERK2 (rat): T183‑p, ERK2 (chicken): T193‑p, ERK2 (cow): T185‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  lung
Cellular systems studied:  tissue
Species studied:  human

Y187-p - ERK2 (human)
Modsite: HtGFLtEyVAtRWyr SwissProt Entrez-Gene
Orthologous residues
ERK2 (human): Y187‑p, ERK2 (mouse): Y185‑p, ERK2 (rat): Y185‑p, ERK2 (chicken): Y195‑p, ERK2 (cow): Y187‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  lung
Cellular systems studied:  tissue
Species studied:  human

S2448-p - mTOR (human)
Modsite: RsRtRtDsysAGQsV SwissProt Entrez-Gene
Orthologous residues
mTOR (human): S2448‑p, mTOR (mouse): S2448‑p, mTOR (rat): S2448‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  lung
Cellular systems studied:  tissue
Species studied:  human

S235-p - S6 (human)
Modsite: IAKRRRLssLRAsts SwissProt Entrez-Gene
Orthologous residues
S6 (human): S235‑p, S6 (mouse): S235‑p, S6 (rat): S235‑p, S6 (fruit fly): A234‑p, S6 (cow): S235‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  lung
Cellular systems studied:  tissue
Species studied:  human
Downstream Regulation
Effect of modification (function):  activity, induced, enzymatic activity, induced
Comments:  eIF4E activation through the AKT pathway leads to progression in NSCLC

S236-p - S6 (human)
Modsite: AKRRRLssLRAstsK SwissProt Entrez-Gene
Orthologous residues
S6 (human): S236‑p, S6 (mouse): S236‑p, S6 (rat): S236‑p, S6 (fruit fly): S235‑p, S6 (cow): S236‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  lung
Cellular systems studied:  tissue
Species studied:  human
Downstream Regulation
Effect of modification (function):  activity, induced, enzymatic activity, induced
Comments:  eIF4E activation through the AKT pathway leads to progression in NSCLC

S664-p - TSC2 (human)
Modsite: KkTSGPLsPPTGPPG SwissProt Entrez-Gene
Orthologous residues
TSC2 (human): S664‑p, TSC2 iso2 (human): S664‑p, TSC2 iso3 (human): S664‑p, TSC2 iso4 (human): S664‑p, TSC2 (mouse): S664‑p, TSC2 iso6 (mouse): S664‑p, TSC2 (rat): S664‑p, TSC2 iso2 (rat): S664‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  lung
Cellular systems studied:  tissue
Species studied:  human
Downstream Regulation
Effect of modification (function):  activity, induced, enzymatic activity, induced
Comments:  eIF4E activation through the AKT pathway leads to progression in NSCLC