Curated Information
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Home > Curated Information Page > PubMed Id: 8195171
Yokote K, et al. (1994) Direct interaction between Shc and the platelet-derived growth factor beta-receptor. J Biol Chem 269, 15337-43 8195171
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y579-p - PDGFRB (human)
Modsite: VSSDGHEyIyVDPMQ SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y579‑p, PDGFRB (mouse): Y578‑p, PDGFRB (rat): Y578‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF increase
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SHC1 (human) SH2 Induces phosphorylation, molecular association, regulation in vitro, co-immunoprecipitation
Comments:  Y579 most important for Shc binding. Phosphorylation of Shc not dependent on individual PDGFRB sites.

Y740-p - PDGFRB (human)
Modsite: TGESDGGyMDMSKDE SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y740‑p, PDGFRB (mouse): Y739‑p, PDGFRB (rat): Y739‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF increase
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SHC1 (human) SH2 Induces molecular association, regulation, phosphorylation in vitro, co-immunoprecipitation
Comments:  Y579 most important for Shc binding. Phosphorylation of Shc not dependent on individual PDGFRB sites.

Y751-p - PDGFRB (human)
Modsite: SKDESVDyVPMLDMK SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y751‑p, PDGFRB (mouse): Y750‑p, PDGFRB (rat): Y750‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF increase
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SHC1 (human) SH2 Induces molecular association, regulation, phosphorylation in vitro, co-immunoprecipitation
Comments:  Y579 most important for Shc binding. Phosphorylation of Shc not dependent on individual PDGFRB sites.

Y771-p - PDGFRB (human)
Modsite: ADIESSNyMAPyDNy SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y771‑p, PDGFRB (mouse): Y770‑p, PDGFRB (rat): Y770‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF increase
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SHC1 (human) SH2 Induces molecular association, regulation, phosphorylation in vitro, co-immunoprecipitation
Comments:  Y579 most important for Shc binding. Phosphorylation of Shc not dependent on individual PDGFRB sites.