Curated Information
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Home > Curated Information Page > PubMed Id: 21980358
Armata HL, et al. (2011) Loss of p53 Ser18 and Atm results in embryonic lethality without cooperation in tumorigenesis. PLoS One 6, e24813 21980358
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S18-p - p53 iso2 (mouse)
Modsite: ISLELPLsQETFSGL SwissProt Entrez-Gene
Orthologous residues
p53 (human): S15‑p, p53 iso2 (human): S15‑p, p53 iso4 (human): , p53 (mouse): S18‑p, p53 iso2 (mouse): S18‑p, p53 (rat): S15‑p, p53 (rabbit): S15‑p, p53 (green monkey): S15‑p
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  thymus [genetic knockin]
Cellular systems studied:  tissue
Species studied:  mouse
Downstream Regulation
Effect of modification (process):  carcinogenesis, altered, cell motility, altered
Comments:  decrease in the growth of p53S18A MEFs with the loss of Atm, lymphomas in 100%Atm-/-, p53 S18A/S18A mice