Armata HL, et al. (2011) Loss of p53 Ser18 and Atm results in embryonic lethality without cooperation in tumorigenesis. PLoS One 6, e24813 21980358

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S18-p - p53 iso2 (mouse) ▲

Modsite: ISLELPLsQETFSGL SwissProt Entrez-Gene Orthologous residues p53 (human): S15‑p, p53 iso2 (human): S15‑p, p53 iso4 (human): ‑, p53 (mouse): S18‑p, p53 iso2 (mouse): S18‑p, p53 (rat): S15‑p, p53 (rabbit): S15‑p, p53 (green monkey): S15‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  thymus [genetic knockin] Cellular systems studied:  tissue Species studied:  mouse Downstream Regulation Effect of modification (process):  carcinogenesis, altered, cell motility, altered Comments:  decrease in the growth of p53S18A MEFs with the loss of Atm, lymphomas in 100%Atm-/-, p53 S18A/S18A mice