Curated Information
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Home > Curated Information Page > PubMed Id: 15572665
Sonnenblick A, Levy C, Razin E (2004) Interplay between MITF, PIAS3, and STAT3 in mast cells and melanocytes. Mol Cell Biol 24, 10584-92 15572665
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S409-p - MITF iso8 (mouse)
Modsite: KTSSRRSsMSAEETE SwissProt Entrez-Gene
Orthologous residues
MITF (human): S516‑p, MITF iso2 (human): S510‑p, MITF iso5 (human): S515‑p, MITF iso9 (human): S409‑p, MITF (mouse): S516‑p, MITF iso8 (mouse): S409‑p, MITF (rat): S516‑p
Characterization
Methods used to characterize site in vivo immunoassay, immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
Disease tissue studied:  melanoma skin cancer
Relevant cell lines - cell types - tissues:  3T3 (fibroblast), B16 (melanocyte), BMMC (mast)
Cellular systems studied:  cell lines
Species studied:  mouse
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE p90RSK (mouse) co-immunoprecipitation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IL-6 increase
SCF increase
Downstream Regulation
Effect of modification (function):  intracellular localization, molecular association, regulation
Effect of modification (process):  transcription, altered
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PIAS3 (mouse) Disrupts co-immunoprecipitation, pull-down assay, microscopy-colocalization