Curated Information
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Home > Curated Information Page > PubMed Id: 21868357
Nobles KN, et al. (2011) Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin. Sci Signal 4, ra51 21868357
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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S246-p - ADRB2 (human)
Modsite: RFHVQNLsQVEQDGR SwissProt Entrez-Gene
Orthologous residues
ADRB2 (human): S246‑p, ADRB2 (mouse): S246‑p, ADRB2 (rat): S246‑p, ADRB2 (hamster): G246‑p

S261-p - ADRB2 (human)
Modsite: TGHGLRRssKFcLKE SwissProt Entrez-Gene
Orthologous residues
ADRB2 (human): S261‑p, ADRB2 (mouse): S261‑p, ADRB2 (rat): S261‑p, ADRB2 (hamster): S261‑p

S262-p - ADRB2 (human)
Modsite: GHGLRRssKFcLKEH SwissProt Entrez-Gene
Orthologous residues
ADRB2 (human): S262‑p, ADRB2 (mouse): S262‑p, ADRB2 (rat): S262‑p, ADRB2 (hamster): S262‑p

S345-p - ADRB2 (human)
Modsite: ELLCLRRssLKAyGN SwissProt Entrez-Gene
Orthologous residues
ADRB2 (human): S345‑p, ADRB2 (mouse): S345‑p, ADRB2 (rat): S345‑p, ADRB2 (hamster): S345‑p

S346-p - ADRB2 (human)
Modsite: LLCLRRssLKAyGNG SwissProt Entrez-Gene
Orthologous residues
ADRB2 (human): S346‑p, ADRB2 (mouse): S346‑p, ADRB2 (rat): S346‑p, ADRB2 (hamster): S346‑p

Y350-p - ADRB2 (human)
Modsite: RRssLKAyGNGyssN SwissProt Entrez-Gene
Orthologous residues
ADRB2 (human): Y350‑p, ADRB2 (mouse): Y350‑p, ADRB2 (rat): Y350‑p, ADRB2 (hamster): Y350‑p

S355-p - ADRB2 (human)
Modsite: KAyGNGyssNGNtGE SwissProt Entrez-Gene
Orthologous residues
ADRB2 (human): S355‑p, ADRB2 (mouse): S355‑p, ADRB2 (rat): S355‑p, ADRB2 (hamster): S355‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE GRK6 (human)
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
carvedilol increase

S356-p - ADRB2 (human)
Modsite: AyGNGyssNGNtGEQ SwissProt Entrez-Gene
Orthologous residues
ADRB2 (human): S356‑p, ADRB2 (mouse): S356‑p, ADRB2 (rat): S356‑p, ADRB2 (hamster): S356‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE GRK6 (human)
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
carvedilol increase

S396-p - ADRB2 (human)
Modsite: GHQGtVPsDNIDsQG SwissProt Entrez-Gene
Orthologous residues
ADRB2 (human): S396‑p, ADRB2 (mouse): S401‑p, ADRB2 (rat): S401‑p, ADRB2 (hamster): S401‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE GRK2 (human)

S407-p - ADRB2 (human)
Modsite: DsQGRNCstNDsLL_ SwissProt Entrez-Gene
Orthologous residues
ADRB2 (human): S407‑p, ADRB2 (mouse): S412‑p, ADRB2 (rat): N412‑p, ADRB2 (hamster): S412‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE GRK2 (human)

S411-p - ADRB2 (human)
Modsite: RNCstNDsLL_____ SwissProt Entrez-Gene
Orthologous residues
ADRB2 (human): S411‑p, ADRB2 (mouse): S416‑p, ADRB2 (rat): S416‑p, ADRB2 (hamster): S416‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE GRK2 (human)

T202-p - ERK1 (human)
Modsite: HDHtGFLtEyVAtRW SwissProt Entrez-Gene
Orthologous residues
ERK1 (human): T202‑p, ERK1 iso2 (human): T202‑p, ERK1 iso3 (human): T202‑p, ERK1 (mouse): T203‑p, ERK1 (rat): T203‑p, ERK1 (hamster): T192‑p

Y204-p - ERK1 (human)
Modsite: HtGFLtEyVAtRWyr SwissProt Entrez-Gene
Orthologous residues
ERK1 (human): Y204‑p, ERK1 iso2 (human): Y204‑p, ERK1 iso3 (human): Y204‑p, ERK1 (mouse): Y205‑p, ERK1 (rat): Y205‑p, ERK1 (hamster): Y194‑p

T185-p - ERK2 (human)
Modsite: HDHtGFLtEyVAtRW SwissProt Entrez-Gene
Orthologous residues
ERK2 (human): T185‑p, ERK2 (mouse): T183‑p, ERK2 (rat): T183‑p, ERK2 (chicken): T193‑p, ERK2 (cow): T185‑p

Y187-p - ERK2 (human)
Modsite: HtGFLtEyVAtRWyr SwissProt Entrez-Gene
Orthologous residues
ERK2 (human): Y187‑p, ERK2 (mouse): Y185‑p, ERK2 (rat): Y185‑p, ERK2 (chicken): Y195‑p, ERK2 (cow): Y187‑p