El-Armouche A, et al. (2011) Phospholemman-dependent regulation of the cardiac Na/K-ATPase activity is modulated by inhibitor-1 sensitive type-1 phosphatase. FASEB J 25, 4467-75 21849407

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S83-p - PLM (rat) ▲

Modsite: EEGtFRSsIRRLstR SwissProt Entrez-Gene Orthologous residues PLM (human): S83‑p, PLM (mouse): S83‑p, PLM (rat): S83‑p, PLM (dog): S83‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  heart, myocyte-heart Cellular systems studied:  primary cultured cells, tissue Species studied:  human, rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes okadaic_acid increase inhibitor-1 no change compared to control I-1-related peptide inhibitor-1, isoproterenol no change compared to control

S88-p - PLM (rat) ▲

Modsite: RSsIRRLstRRR___ SwissProt Entrez-Gene Orthologous residues PLM (human): S88‑p, PLM (mouse): S88‑p, PLM (rat): S88‑p, PLM (dog): S88‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  heart, myocyte-heart Cellular systems studied:  primary cultured cells, tissue Species studied:  human, rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes okadaic_acid increase inhibitor-1 decrease I-1 related peptide inhibitor-1, isoproterenol increase Downstream Regulation Effect of modification (function):  activity, induced Comments:  Na/K-ATPase activity Associated Diseases Diseases Alterations Comments cardiomyopathy decreased

T89-p - PLM (rat) ▲

Modsite: SsIRRLstRRR____ SwissProt Entrez-Gene Orthologous residues PLM (human): T89‑p, PLM (mouse): S89‑p, PLM (rat): T89‑p, PLM (dog): T89‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  heart, myocyte-heart Cellular systems studied:  primary cultured cells, tissue Species studied:  human, rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes okadaic_acid increase inhibitor-1 no change compared to control I-1-related peptide inhibitor-1, isoproterenol no change compared to control