Curated Information
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Home > Curated Information Page > PubMed Id: 21865164
Adwan TS, et al. (2011) Regulated binding of importin-α to protein kinase Cδ in response to apoptotic signals facilitates nuclear import. J Biol Chem 286, 35716-24 21865164
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y64-p - PKCD (mouse)
Modsite: TTFDAHIyEGRVIQI SwissProt Entrez-Gene
Orthologous residues
PKCD (human): Y64‑p, PKCD iso2 (human): Y64‑p, PKCD (mouse): Y64‑p, PKCD iso2 (mouse): Y64‑p, PKCD (rat): Y64‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
H2O2 increase
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
KPNA2 (human) Induces co-immunoprecipitation

Y155-p - PKCD (mouse)
Modsite: IKQAKIHyIKNHEFI SwissProt Entrez-Gene
Orthologous residues
PKCD (human): Y155‑p, PKCD iso2 (human): Y155‑p, PKCD (mouse): Y155‑p, PKCD iso2 (mouse): Y155‑p, PKCD (rat): Y155‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
H2O2 increase
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
KPNA2 (human) Induces co-immunoprecipitation

Y64-p - PKCD (rat)
Modsite: STFDAHIyEGRVIQI SwissProt Entrez-Gene
Orthologous residues
PKCD (human): Y64‑p, PKCD iso2 (human): Y64‑p, PKCD (mouse): Y64‑p, PKCD iso2 (mouse): Y64‑p, PKCD (rat): Y64‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

Y155-p - PKCD (rat)
Modsite: IKQAKIHyIKNHEFI SwissProt Entrez-Gene
Orthologous residues
PKCD (human): Y155‑p, PKCD iso2 (human): Y155‑p, PKCD (mouse): Y155‑p, PKCD iso2 (mouse): Y155‑p, PKCD (rat): Y155‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human