James TT, Aroor AR, Lim RW, Shukla SD (2012) Histone H3 phosphorylation (Ser10, Ser28) and phosphoacetylation (K9S10) are differentially associated with gene expression in liver of rats treated in vivo with acute ethanol. J Pharmacol Exp Ther 340, 237-47 22025646

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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K9-ac - H3 (rat) ▲

Modsite: RtkQTARkstGGkAP SwissProt Entrez-Gene Orthologous residues H3 (human): K9‑ac, H3 (mouse): K9‑ac, H3 iso2 (mouse): K9‑ac, H3 iso3 (mouse): K9‑ac, H3 (rat): K9‑ac, H3 iso3 (rat): K9‑ac, H3 (pig): K9‑ac, H3 (chicken): K9‑ac, H3 (cow): K9‑ac Characterization Methods used to characterize site in vivo:  immunoprecipitation, modification-specific antibody Relevant cell lines - cell types - tissues:  liver Cellular systems studied:  tissue Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes ethanol increase 1-3.5g/kg ethanol

S10-p - H3 (rat) ▲

Modsite: tkQTARkstGGkAPR SwissProt Entrez-Gene Orthologous residues H3 (human): S10‑p, H3 (mouse): S10‑p, H3 iso2 (mouse): S10‑p, H3 iso3 (mouse): S10‑p, H3 (rat): S10‑p, H3 iso3 (rat): S10‑p, H3 (pig): S10‑p, H3 (chicken): S10‑p, H3 (cow): S10‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, modification-specific antibody Relevant cell lines - cell types - tissues:  liver Cellular systems studied:  tissue Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes ethanol no change compared to control 5g/kg Ethanol ethanol increase 1.75 and 3.5g/kg ethanol

S28-p - H3 (rat) ▲

Modsite: ATkAARksAPATGGV SwissProt Entrez-Gene Orthologous residues H3 (human): S28‑p, H3 (mouse): S28‑p, H3 iso2 (mouse): S28‑p, H3 iso3 (mouse): S28‑p, H3 (rat): S28‑p, H3 iso3 (rat): S28‑p, H3 (pig): S28‑p, H3 (chicken): S28‑p, H3 (cow): S28‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, modification-specific antibody Relevant cell lines - cell types - tissues:  liver Cellular systems studied:  tissue Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes ethanol no change compared to control 5g/kg Ethanol ethanol increase 1.75, 2.5 and 3.5 g/kg ethanol Downstream Regulation Effect of modification (process):  transcription, induced Comments:  at c-Jun and PAI gene promoters