Curated Information
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Home > Curated Information Page > PubMed Id: 12700239
Song DH, et al. (2003) CK2 phosphorylation of the armadillo repeat region of beta-catenin potentiates Wnt signaling. J Biol Chem 278, 24018-25 12700239
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T393-p - CTNNB1 (human)
Modsite: RNLSDAAtkQEGMEG SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): T393‑p, CTNNB1 (mouse): T393‑p, CTNNB1 (rat): T393‑p, CTNNB1 (rabbit): T393‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  COS (fibroblast)
Cellular systems studied:  cell lines
Species studied:  green monkey
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK2A1 (mouse)
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
apigenin decrease
wortmannin no change compared to control
Downstream Regulation
Effect of modification (function):  protein stabilization
Effect of modification (process):  transcription, induced
Comments:  Underphosphorylated T393A mutant has reduced stability and co-transcriptional activity.

T393-p - CTNNB1 (mouse)
Modsite: RNLSDAAtKQEGMEG SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): T393‑p, CTNNB1 (mouse): T393‑p, CTNNB1 (rat): T393‑p, CTNNB1 (rabbit): T393‑p