Curated Information
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Home > Curated Information Page > PubMed Id: 21896937
McCormick JA, et al. (2011) Overexpression of the sodium chloride cotransporter is not sufficient to cause familial hyperkalemic hypertension. Hypertension 58, 888-94 21896937
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T53-p - NCCT (mouse)
Modsite: GstLyMRtFGYNtID SwissProt Entrez-Gene
Orthologous residues
NCCT (human): T55‑p, NCCT iso2 (human): T55‑p, NCCT iso3 (human): T55‑p, NCCT (mouse): T53‑p, NCCT (rat): T53‑p
Characterization
Methods used to characterize site in vivo immunoassay, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  kidney
Cellular systems studied:  tissue
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
high-potassium diet decrease
high-potassium diet NCCT (mouse) inhibit treatment-induced decrease
NCCT (mouse) decrease T53 phosphorylated ratio to total NCCT decreased 41% relative to wild-type controls.