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Home > Curated Information Page > PubMed Id: 18276596
Taylor EB, et al. (2008) Discovery of TBC1D1 as an insulin-, AICAR-, and contraction-stimulated signaling nexus in mouse skeletal muscle. J Biol Chem 283, 9787-96 18276596
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S231-p - TBC1D1 (mouse)
Modsite: RPMRKsFsQPGLRSL SwissProt Entrez-Gene
Orthologous residues
TBC1D1 (human): S237‑p, TBC1D1 iso2 (human): S237‑p, TBC1D1 (mouse): S231‑p, TBC1D1 iso2 (mouse): S231‑p, TBC1D1 (rat): S231‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  mouse
Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt1 (human)
KINASE AMPKA1 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE AMPKA1 (mouse) electrophoretic mobility shift, activation of upstream enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase
muscle contraction increase
acadesine increase

T253-p - TBC1D1 (mouse)
Modsite: DASLRSStFssFDND SwissProt Entrez-Gene
Orthologous residues
TBC1D1 (human): , TBC1D1 iso2 (human): , TBC1D1 (mouse): T253‑p, TBC1D1 iso2 (mouse): T253‑p, TBC1D1 (rat): T253‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  mouse
Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt1 (human)
KINASE AMPKA1 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE AMPKA1 (mouse) electrophoretic mobility shift, activation of upstream enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase
muscle contraction increase
acadesine increase

T499-p - TBC1D1 (mouse)
Modsite: NRAKRsLtEsLEsIL SwissProt Entrez-Gene
Orthologous residues
TBC1D1 (human): T505‑p, TBC1D1 iso2 (human): T505‑p, TBC1D1 (mouse): T499‑p, TBC1D1 iso2 (mouse): T499‑p, TBC1D1 (rat): T499‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  mouse
Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt1 (human)
KINASE AMPKA1 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE AMPKA1 (mouse) electrophoretic mobility shift, activation of upstream enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
acadesine increase

T590-p - TBC1D1 (mouse)
Modsite: AFRRRANtLsHFPVE SwissProt Entrez-Gene
Orthologous residues
TBC1D1 (human): T596‑p, TBC1D1 iso2 (human): T596‑p, TBC1D1 (mouse): T590‑p, TBC1D1 iso2 (mouse): T590‑p, TBC1D1 (rat): T590‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  mouse
Enzymes shown to modify site in vitro
Type Enzyme
KINASE AMPKA1 (human)
KINASE Akt1 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE AMPKA1 (mouse) electrophoretic mobility shift, activation of upstream enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase
muscle contraction increase
acadesine increase

S621-p - TBC1D1 (mouse)
Modsite: RKLMRYHsVstETPH SwissProt Entrez-Gene
Orthologous residues
TBC1D1 (human): S627‑p, TBC1D1 iso2 (human): S627‑p, TBC1D1 (mouse): S621‑p, TBC1D1 iso2 (mouse): S621‑p, TBC1D1 (rat): S621‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  mouse
Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt1 (human)
KINASE AMPKA1 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE AMPKA1 (mouse) electrophoretic mobility shift, activation of upstream enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase
muscle contraction increase
acadesine increase

S660-p - TBC1D1 (mouse)
Modsite: PRLNPSAssPNFFKY SwissProt Entrez-Gene
Orthologous residues
TBC1D1 (human): , TBC1D1 iso2 (human): S667‑p, TBC1D1 (mouse): S660‑p, TBC1D1 iso2 (mouse): , TBC1D1 (rat): S662‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  mouse
Enzymes shown to modify site in vitro
Type Enzyme
KINASE AMPKA1 (human)
KINASE Akt1 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE AMPKA1 (mouse) electrophoretic mobility shift, activation of upstream enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase
muscle contraction increase
acadesine increase

S700-p - TBC1D1 (mouse)
Modsite: KKLHssssVPNFLKF SwissProt Entrez-Gene
Orthologous residues
TBC1D1 (human): , TBC1D1 iso2 (human): S707‑p, TBC1D1 (mouse): S700‑p, TBC1D1 iso2 (mouse): , TBC1D1 (rat): S702‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  mouse
Enzymes shown to modify site in vitro
Type Enzyme
KINASE AMPKA1 (human)
KINASE Akt1 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE AMPKA1 (mouse) electrophoretic mobility shift, activation of upstream enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase
muscle contraction increase
acadesine increase