Curated Information
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Home > Curated Information Page > PubMed Id: 17965600
Goyal R, et al. (2007) Phosphorylation of serine-515 activates the Mammalian maintenance methyltransferase Dnmt1. Epigenetics 2, 155-60 17965600
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S84-p - DNMT1 (mouse)
Modsite: GYLAKVKsLLNKDLS SwissProt Entrez-Gene
Orthologous residues
DNMT1 (human): S84‑p, DNMT1 iso2 (human): S84‑p, DNMT1 (mouse): S84‑p, DNMT1 (rat): T84‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Sf21
Cellular systems studied:  cell lines
Species studied:  fruit fly

S128-p - DNMT1 (mouse)
Modsite: DsNRsPRsRPKPRGP SwissProt Entrez-Gene
Orthologous residues
DNMT1 (human): P131‑p, DNMT1 iso2 (human): P131‑p, DNMT1 (mouse): S128‑p, DNMT1 (rat): S128‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Sf21
Cellular systems studied:  cell lines
Species studied:  fruit fly

S249-p - DNMT1 (mouse)
Modsite: RRHtRELsLRRKsKE SwissProt Entrez-Gene
Orthologous residues
DNMT1 (human): T253‑p, DNMT1 iso2 (human): T269‑p, DNMT1 (mouse): S249‑p, DNMT1 (rat): A249‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Sf21
Cellular systems studied:  cell lines
Species studied:  fruit fly

S254-p - DNMT1 (mouse)
Modsite: ELsLRRKsKEDPDRE SwissProt Entrez-Gene
Orthologous residues
DNMT1 (human): L258‑p, DNMT1 iso2 (human): L274‑p, DNMT1 (mouse): S254‑p, DNMT1 (rat): S254‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Sf21
Cellular systems studied:  cell lines
Species studied:  fruit fly

S285-p - DNMT1 (mouse)
Modsite: KRssRPRsQPRDPAA SwissProt Entrez-Gene
Orthologous residues
DNMT1 (human): S288‑p, DNMT1 iso2 (human): S304‑p, DNMT1 (mouse): S285‑p, DNMT1 (rat): S285‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Sf21
Cellular systems studied:  cell lines
Species studied:  fruit fly

S498-p - DNMT1 (mouse)
Modsite: EYILMEPsKEYEPIF SwissProt Entrez-Gene
Orthologous residues
DNMT1 (human): S492‑p, DNMT1 iso2 (human): S508‑p, DNMT1 (mouse): S498‑p, DNMT1 (rat): S498‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Sf21
Cellular systems studied:  cell lines
Species studied:  fruit fly

S515-p - DNMT1 (mouse)
Modsite: MQEKIYIsKIVVEFL SwissProt Entrez-Gene
Orthologous residues
DNMT1 (human): S509‑p, DNMT1 iso2 (human): S525‑p, DNMT1 (mouse): S515‑p, DNMT1 (rat): S515‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, mutation of modification site
Relevant cell lines - cell types - tissues:  Sf21
Cellular systems studied:  cell lines
Species studied:  fruit fly
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced, protein conformation
Comments:  important for an interaction between the N-terminal and the catalytic domain of DNMT1

S597-p - DNMT1 (mouse)
Modsite: LIHLAGVsLGQRRAt SwissProt Entrez-Gene
Orthologous residues
DNMT1 (human): T591‑p, DNMT1 iso2 (human): T607‑p, DNMT1 (mouse): S597‑p, DNMT1 (rat): S597‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Sf21
Cellular systems studied:  cell lines
Species studied:  fruit fly

S958-p - DNMT1 (mouse)
Modsite: TFNIKVAsPVKRPKK SwissProt Entrez-Gene
Orthologous residues
DNMT1 (human): S954‑p, DNMT1 iso2 (human): S970‑p, DNMT1 (mouse): S958‑p, DNMT1 (rat): S958‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Sf21
Cellular systems studied:  cell lines
Species studied:  fruit fly

S1108-p - DNMT1 (mouse)
Modsite: DPPNHARsPGNKGKG SwissProt Entrez-Gene
Orthologous residues
DNMT1 (human): S1105‑p, DNMT1 iso2 (human): S1121‑p, DNMT1 (mouse): S1108‑p, DNMT1 (rat): S1110‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Sf21
Cellular systems studied:  cell lines
Species studied:  fruit fly

S1249-p - DNMT1 (mouse)
Modsite: TYSKFKNsLVVsFLS SwissProt Entrez-Gene
Orthologous residues
DNMT1 (human): S1246‑p, DNMT1 iso2 (human): S1262‑p, DNMT1 (mouse): S1249‑p, DNMT1 (rat): S1251‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Sf21
Cellular systems studied:  cell lines
Species studied:  fruit fly

S1253-p - DNMT1 (mouse)
Modsite: FKNsLVVsFLSYCDY SwissProt Entrez-Gene
Orthologous residues
DNMT1 (human): S1250‑p, DNMT1 iso2 (human): S1266‑p, DNMT1 (mouse): S1253‑p, DNMT1 (rat): S1255‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Sf21
Cellular systems studied:  cell lines
Species studied:  fruit fly

S1421-p - DNMT1 (mouse)
Modsite: DHICKDMsPLVAARM SwissProt Entrez-Gene
Orthologous residues
DNMT1 (human): S1418‑p, DNMT1 iso2 (human): S1434‑p, DNMT1 (mouse): S1421‑p, DNMT1 (rat): A1405‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Sf21
Cellular systems studied:  cell lines
Species studied:  fruit fly

S1495-p - DNMT1 (mouse)
Modsite: DPESRQFsTLIPWCL SwissProt Entrez-Gene
Orthologous residues
DNMT1 (human): N1493‑p, DNMT1 iso2 (human): N1509‑p, DNMT1 (mouse): S1495‑p, DNMT1 (rat): N1497‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Sf21
Cellular systems studied:  cell lines
Species studied:  fruit fly