Curated Information
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Home > Curated Information Page > PubMed Id: 21719704
Yu X, et al. (2011) Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrate. J Biol Chem 286, 30526-34 21719704
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y75-p - SKAP2 (human)
Modsite: DAEDGEEyDDPFAGP SwissProt Entrez-Gene
Orthologous residues
SKAP2 (human): Y75‑p, SKAP2 (mouse): Y75‑p, SKAP2 (rat): Y75‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, western blotting
Relevant cell lines - cell types - tissues:  RAW 264.7 (macrophage)
Cellular systems studied:  cell lines
Species studied:  mouse
Enzymes shown to modify site in vitro
Type Enzyme
PHOSPHATASE PTPN22 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
PHOSPHATASE PTPN22 (human) co-immunoprecipitation
Downstream Regulation
Effect of modification (function):  protein conformation