Annamalai B, et al. (2012) Tyrosine phosphorylation of the human serotonin transporter: a role in the transporter stability and function. Mol Pharmacol 81, 73-85 21992875

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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Y47-p - SERT (human) ▲

Modsite: SGQISNGysAVPSPG SwissProt Entrez-Gene Orthologous residues SERT (human): Y47‑p, SERT iso2 (human): Y89‑p, SERT (mouse): Y47‑p, SERT (rat): Y47‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HTR (mast) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE Src (human) siRNA inhibition of enzyme, phospho-antibody, transfection of wild-type enzyme, pharmacological inhibitor of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes siRNA decrease Src-siRNA PP2 decrease Downstream Regulation Effect of modification (function):  activity, induced, protein stabilization Comments:  increases 5-HT uptake

Y142-p - SERT (human) ▲

Modsite: MELALGQyHRNGCIs SwissProt Entrez-Gene Orthologous residues SERT (human): Y142‑p, SERT iso2 (human): Y184‑p, SERT (mouse): Y142‑p, SERT (rat): Y142‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HTR (mast) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE Src (human) siRNA inhibition of enzyme, phospho-antibody, transfection of wild-type enzyme, pharmacological inhibitor of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes siRNA decrease Src-siRNA PP2 decrease Downstream Regulation Effect of modification (function):  activity, induced, protein stabilization Comments:  increases 5-HT uptake