Curated Information
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Home > Curated Information Page > PubMed Id: 22025562
Li L, et al. (2011) GLIPR1 suppresses prostate cancer development through targeted oncoprotein destruction. Cancer Res 71, 7694-704 22025562
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S33-p - CTNNB1 (human)
Modsite: QQQsyLDsGIHsGAT SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): S33‑p, CTNNB1 (mouse): S33‑p, CTNNB1 (rat): S33‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
GLIPR1 (human) increase
Downstream Regulation
Effect of modification (function):  protein degradation
Effect of modification (process):  transcription, inhibited
Comments:  c-Myc transcription inhibited

S37-p - CTNNB1 (human)
Modsite: yLDsGIHsGATtTAP SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): S37‑p, CTNNB1 (mouse): S37‑p, CTNNB1 (rat): S37‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
GLIPR1 (human) increase
Downstream Regulation
Effect of modification (function):  protein degradation
Effect of modification (process):  transcription, inhibited
Comments:  c-Myc transcription inhibited

T41-p - CTNNB1 (human)
Modsite: GIHsGATtTAPsLsG SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): T41‑p, CTNNB1 (mouse): T41‑p, CTNNB1 (rat): T41‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
GLIPR1 (human) increase
Downstream Regulation
Effect of modification (function):  protein degradation
Effect of modification (process):  transcription, inhibited
Comments:  c-Myc transcription inhibited

T58-p - Myc (human)
Modsite: kkFELLPtPPLsPsR SwissProt Entrez-Gene
Orthologous residues
Myc (human): T58‑p, Myc iso2 (human): T73‑p, Myc (mouse): T58‑p, Myc (rat): T58‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE GSK3B (human) transfection of wild-type enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
GLIPR1 (human) increase
Downstream Regulation
Effect of modification (function):  protein degradation, ubiquitination
Comments:  S252 was the primary site for Myc degradation.

S62-p - Myc (human)
Modsite: LLPtPPLsPsRRsGL SwissProt Entrez-Gene
Orthologous residues
Myc (human): S62‑p, Myc iso2 (human): S77‑p, Myc (mouse): S62‑p, Myc (rat): S62‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE GSK3B (human) transfection of wild-type enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
GLIPR1 (human) increase
Downstream Regulation
Effect of modification (function):  phosphorylation
Comments:  phosphorylation at the priming site S62 induces phosphorylation at T58

S67-p - Myc (human)
Modsite: PLsPsRRsGLCsPSy SwissProt Entrez-Gene
Orthologous residues
Myc (human): S67‑p, Myc iso2 (human): S82‑p, Myc (mouse): S67‑p, Myc (rat): S67‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CK1A (human) transfection of wild-type enzyme, siRNA inhibition of enzyme
Downstream Regulation
Effect of modification (function):  protein degradation, ubiquitination
Comments:  S252 was the primary site for Myc degradation.

S252-p - Myc (human)
Modsite: PPTTssDsEEEQEDE SwissProt Entrez-Gene
Orthologous residues
Myc (human): S252‑p, Myc iso2 (human): S267‑p, Myc (mouse): S252‑p, Myc (rat): S252‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CK1A (human) transfection of wild-type enzyme, siRNA inhibition of enzyme
Downstream Regulation
Effect of modification (function):  protein degradation, ubiquitination
Comments:  S252 was the primary site for Myc degradation.