Curated Information
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.6.0.4
Powered by Cell Signaling Technology
Home > Curated Information Page > PubMed Id: 21278788
Jung J, et al. (2011) Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of Src. Oncogene 30, 2264-74 21278788
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
Download

S473-p - Akt1 (human)
Modsite: RPHFPQFsysAsGtA SwissProt Entrez-Gene
Orthologous residues
Akt1 (human): S473‑p, Akt1 iso2 (human): S411‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer
Relevant cell lines - cell types - tissues:  MCF-7 (breast cell), MCF10A1 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

Y869-p - EGFR (human)
Modsite: LGAEEkEyHAEGGkV SwissProt Entrez-Gene
Orthologous residues
EGFR (human): Y869‑p, EGFR iso2 (human): , EGFR iso5 (human): Y869‑p, EGFR (mouse): Y871‑p, EGFR (rat): Y870‑p, EGFR (pig): Y869‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer
Relevant cell lines - cell types - tissues:  MCF-7 (breast cell), MCF10A1 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

Y1016-p - EGFR (human)
Modsite: DVVDADEyLIPQQGF SwissProt Entrez-Gene
Orthologous residues
EGFR (human): Y1016‑p, EGFR iso2 (human): , EGFR iso5 (human): Y1016‑p, EGFR (mouse): Y1018‑p, EGFR (rat): Y1017‑p, EGFR (pig): Y1016‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer
Relevant cell lines - cell types - tissues:  MCF-7 (breast cell), MCF10A1 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

Y1092-p - EGFR (human)
Modsite: tFLPVPEyINQsVPk SwissProt Entrez-Gene
Orthologous residues
EGFR (human): Y1092‑p, EGFR iso2 (human): , EGFR iso5 (human): , EGFR (mouse): Y1092‑p, EGFR (rat): Y1091‑p, EGFR (pig): Y1091‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer
Relevant cell lines - cell types - tissues:  MCF-7 (breast cell), MCF10A1 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

Y1110-p - EGFR (human)
Modsite: GsVQNPVyHNQPLNP SwissProt Entrez-Gene
Orthologous residues
EGFR (human): Y1110‑p, EGFR iso2 (human): , EGFR iso5 (human): , EGFR (mouse): Y1110‑p, EGFR (rat): Y1109‑p, EGFR (pig): Y1109‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer
Relevant cell lines - cell types - tissues:  MCF-7 (breast cell), MCF10A1 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

Y1172-p - EGFR (human)
Modsite: IsLDNPDyQQDFFPk SwissProt Entrez-Gene
Orthologous residues
EGFR (human): Y1172‑p, EGFR iso2 (human): , EGFR iso5 (human): , EGFR (mouse): Y1172‑p, EGFR (rat): Y1171‑p, EGFR (pig): Y1171‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer
Relevant cell lines - cell types - tissues:  MCF-7 (breast cell), MCF10A1 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

Y1197-p - EGFR (human)
Modsite: stAENAEyLRVAPQS SwissProt Entrez-Gene
Orthologous residues
EGFR (human): Y1197‑p, EGFR iso2 (human): , EGFR iso5 (human): , EGFR (mouse): Y1197‑p, EGFR (rat): Y1196‑p, EGFR (pig): Y1196‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer
Relevant cell lines - cell types - tissues:  MCF-7 (breast cell), MCF10A1 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

T202-p - ERK1 (human)
Modsite: HDHtGFLtEyVAtRW SwissProt Entrez-Gene
Orthologous residues
ERK1 (human): T202‑p, ERK1 iso2 (human): T202‑p, ERK1 iso3 (human): T202‑p, ERK1 (mouse): T203‑p, ERK1 (rat): T203‑p, ERK1 (hamster): T192‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer
Relevant cell lines - cell types - tissues:  MCF-7 (breast cell), MCF10A1 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

Y204-p - ERK1 (human)
Modsite: HtGFLtEyVAtRWyr SwissProt Entrez-Gene
Orthologous residues
ERK1 (human): Y204‑p, ERK1 iso2 (human): Y204‑p, ERK1 iso3 (human): Y204‑p, ERK1 (mouse): Y205‑p, ERK1 (rat): Y205‑p, ERK1 (hamster): Y194‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer
Relevant cell lines - cell types - tissues:  MCF-7 (breast cell), MCF10A1 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

T185-p - ERK2 (human)
Modsite: HDHtGFLtEyVAtRW SwissProt Entrez-Gene
Orthologous residues
ERK2 (human): T185‑p, ERK2 (mouse): T183‑p, ERK2 (rat): T183‑p, ERK2 (chicken): T193‑p, ERK2 (cow): T185‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer
Relevant cell lines - cell types - tissues:  MCF-7 (breast cell), MCF10A1 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

Y187-p - ERK2 (human)
Modsite: HtGFLtEyVAtRWyr SwissProt Entrez-Gene
Orthologous residues
ERK2 (human): Y187‑p, ERK2 (mouse): Y185‑p, ERK2 (rat): Y185‑p, ERK2 (chicken): Y195‑p, ERK2 (cow): Y187‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer
Relevant cell lines - cell types - tissues:  MCF-7 (breast cell), MCF10A1 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

S218-p - MEK1 (human)
Modsite: VsGQLIDsMANsFVG SwissProt Entrez-Gene
Orthologous residues
MEK1 (human): S218‑p, MEK1 iso2 (human): S192‑p, MEK1 (mouse): S218‑p, MEK1 (rat): S218‑p, MEK1 (rabbit): S218‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer
Relevant cell lines - cell types - tissues:  MCF-7 (breast cell), MCF10A1 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

S222-p - MEK1 (human)
Modsite: LIDsMANsFVGtRSY SwissProt Entrez-Gene
Orthologous residues
MEK1 (human): S222‑p, MEK1 iso2 (human): S196‑p, MEK1 (mouse): S222‑p, MEK1 (rat): S222‑p, MEK1 (rabbit): S222‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer
Relevant cell lines - cell types - tissues:  MCF-7 (breast cell), MCF10A1 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

S222-p - MEK2 (human)
Modsite: VsGQLIDsMANsFVG SwissProt Entrez-Gene
Orthologous residues
MEK2 (human): S222‑p, MEK2 (mouse): S222‑p, MEK2 (rat): S222‑p, MEK2 (chicken): S220‑p, MEK2 (cow): S222‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer
Relevant cell lines - cell types - tissues:  MCF-7 (breast cell), MCF10A1 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

S226-p - MEK2 (human)
Modsite: LIDsMANsFVGtRSY SwissProt Entrez-Gene
Orthologous residues
MEK2 (human): S226‑p, MEK2 (mouse): S226‑p, MEK2 (rat): S226‑p, MEK2 (chicken): S224‑p, MEK2 (cow): S226‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer
Relevant cell lines - cell types - tissues:  MCF-7 (breast cell), MCF10A1 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

S218-p - MKK3 (human)
Modsite: IsGyLVDsVAKtMDA SwissProt Entrez-Gene
Orthologous residues
MKK3 (human): S218‑p, MKK3 iso2 (human): S189‑p, MKK3 iso3 (human): S223‑p, MKK3 (mouse): S218‑p, MKK3 (rat): S290‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer
Relevant cell lines - cell types - tissues:  MCF-7 (breast cell), MCF10A1 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

S207-p - MKK6 (human)
Modsite: IsGyLVDsVAKtIDA SwissProt Entrez-Gene
Orthologous residues
MKK6 (human): S207‑p, MKK6 iso2 (human): S151‑p, MKK6 (mouse): S207‑p, MKK6 (rat): S207‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer
Relevant cell lines - cell types - tissues:  MCF-7 (breast cell), MCF10A1 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

S199-p - PAK1 (human)
Modsite: PRPEHtKsVyTRsVI SwissProt Entrez-Gene
Orthologous residues
PAK1 (human): S199‑p, PAK1 (mouse): S199‑p, PAK1 (rat): S198‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer
Relevant cell lines - cell types - tissues:  MCF-7 (breast cell), MCF10A1 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

S204-p - PAK1 (human)
Modsite: tKsVyTRsVIEPLPV SwissProt Entrez-Gene
Orthologous residues
PAK1 (human): S204‑p, PAK1 (mouse): S204‑p, PAK1 (rat): S203‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer
Relevant cell lines - cell types - tissues:  MCF-7 (breast cell), MCF10A1 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

Y467-p - PIK3R1 (human)
Modsite: SREyDRLyEEytRTS SwissProt Entrez-Gene
Orthologous residues
PIK3R1 (human): Y467‑p, PIK3R1 iso2 (human): Y197‑p, PIK3R1 iso4 (human): Y467‑p, PIK3R1 (mouse): Y467‑p, PIK3R1 (rat): Y467‑p, PIK3R1 (cow): Y467‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer
Relevant cell lines - cell types - tissues:  MCF-7 (breast cell), MCF10A1 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

Y199-p - PIK3R3 (human)
Modsite: SKEyDRLyEEytRTS SwissProt Entrez-Gene
Orthologous residues
PIK3R3 (human): Y199‑p, PIK3R3 iso2 (human): Y199‑p, PIK3R3 (mouse): Y199‑p, PIK3R3 (rat): Y199‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer
Relevant cell lines - cell types - tissues:  MCF-7 (breast cell), MCF10A1 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

Y783-p - PLCG1 (human)
Modsite: EGRNPGFyVEANPMP SwissProt Entrez-Gene
Orthologous residues
PLCG1 (human): Y783‑p, PLCG1 iso2 (human): Y783‑p, PLCG1 (mouse): Y783‑p, PLCG1 (rat): Y783‑p, PLCG1 (cow): Y783‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer
Relevant cell lines - cell types - tissues:  MCF-7 (breast cell), MCF10A1 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

S338-p - RAF1 (human)
Modsite: RPRGQRDssyyWEIE SwissProt Entrez-Gene
Orthologous residues
RAF1 (human): S338‑p, RAF1 iso2 (human): S358‑p, RAF1 (mouse): S338‑p, RAF1 (rat): S338‑p, RAF1 (chicken): S338‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer
Relevant cell lines - cell types - tissues:  MCF-7 (breast cell), MCF10A1 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

Y419-p - Src (human)
Modsite: RLIEDNEytARQGAk SwissProt Entrez-Gene
Orthologous residues
Src (human): Y419‑p, Src iso2 (human): Y425‑p, Src (mouse): Y418‑p, Src iso1 (mouse): Y424‑p, Src (rat): Y419‑p, Src (chicken): Y416‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer
Relevant cell lines - cell types - tissues:  MCF-7 (breast cell), MCF10A1 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human